Meta-analysis of dose-response characteristics of hydrochlorothiazide and chlorthalidone: effects on systolic blood pressure and potassium.

@article{Ernst2010MetaanalysisOD,
  title={Meta-analysis of dose-response characteristics of hydrochlorothiazide and chlorthalidone: effects on systolic blood pressure and potassium.},
  author={Michael E. Ernst and Barry L Carter and Shimin Zheng and Richard H. Grimm},
  journal={American journal of hypertension},
  year={2010},
  volume={23 4},
  pages={440-6}
}
BACKGROUND Evidence supporting the benefit of low-dose thiazide-based regimens to reduce cardiovascular events is primarily derived from studies using chlorthalidone, yet low-dose hydrochlorothiazide (HCTZ) (12.5-25 mg) remains more widely prescribed. We sought to describe their comparative dose-response relationships for changes in systolic blood pressure (SBP) and potassium. METHODS PubMed from 1948 to July 2008 was systematically searched to identify clinical trials using either HCTZ or… CONTINUE READING
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