Meta-analysis of clinical and preclinical studies comparing the anticancer efficacy of liposomal versus conventional non-liposomal doxorubicin.

@article{Petersen2016MetaanalysisOC,
  title={Meta-analysis of clinical and preclinical studies comparing the anticancer efficacy of liposomal versus conventional non-liposomal doxorubicin.},
  author={Grant H Petersen and Saeed K Alzghari and Wayne Chee and Sana S Sankari and Ninh M. La-Beck},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2016},
  volume={232},
  pages={255-64}
}
While liposome-mediated delivery of cytotoxic chemotherapy has been shown to significantly enhance drug tolerability in patients as compared to the conventional formulation, the fundamental question remains whether they also improve anticancer efficacy. Thus, we performed a systematic literature search for randomized clinical trials directly comparing efficacy of liposomal cytotoxic chemotherapy versus their equivalent conventional formulation. The search yielded 14 clinical trials (8… CONTINUE READING
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