Meta-analysis of brain weight in schizophrenia

  title={Meta-analysis of brain weight in schizophrenia},
  author={Paul J. Harrison and Nick Freemantle and John R. Geddes},
  journal={Schizophrenia Research},
Brain volume in first-episode schizophrenia
Average volumetric changes are close to the limit of detection by MRI methods, indicating whether schizophrenia is a neurodegenerative process that begins at about the time of symptom onset, or whether it is better characterised as a neurodevelopmental process that produces abnormal brain volumes at an early age.
Neural correlates of cognitive impairment in schizophrenia
Cognitive impairment in schizophrenia is not a function of the structural brain abnormality that accompanies the disorder but has correlates in altered brain function.
Regional thinning of the cerebral cortex in schizophrenia: Effects of diagnosis, age and antipsychotic medication
Neuropathology of schizophrenia
The observed changes in the size, density, and synaptic connections of neurons in several brain areas, especially the hippocampus, frontal cortex, and thalamus are consistent with a subtle change in the synaptic organization of the brain in schizophrenia.
Examining the neuropsychological functioning of a representative sample of schizophrenia patients and their family members to estimate the heritability of the cognitive traits and to evaluate the number of their contributing loci aimed at identifying clusters of families with schizophrenia that show convergent cognitive functioning.
Neuroimaging and molecular genetics of schizophrenia: pathophysiological advances and therapeutic potential
The NRG1 gene appears to be a risk factor for an extended or intermediate phenotype, while the COMT Val allele is associated with an increased risk of schizophrenia in subjects at increased familial risk.
Brain MRI in subjects with schizophrenia and in adults born prematurely : the Northern Finland 1966 Birth Cohort Study
MRI changes of the brain in subjects with schizophrenia at age 33–35 years confirmed previous findings of brain abnormalities in schizophrenia in an epidemiological population-based sample.


Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder.
The findings provide postmortem confirmation of reports of ventricular enlargement in radiological studies and suggest that such enlargement is associated with tissue loss in the temporal lobe.
Meta-analysis of regional brain volumes in schizophrenia.
OBJECTIVE The authors' goal was to determine whether patients with schizophrenia differ from comparison subjects in regional brain volumes and whether these differences are similar in male and female
Meta-analysis of brain and cranial size in schizophrenia
Is there a neuropathology of schizophrenia?
Is There a Neuroanatomic Basis for Schizophrenia? An Old Question Revisited
Overall, many investigators now consider schizophrenia to be a neurodevel opmental disorder in which a latent defect present from birth requires normal maturational changes in the brain to trigger the characteristic onset of illness during adolescence and early adulthood.
No increased incidence of Alzheimer’s disease in elderly schizophrenics
Abstract There is currently controversy as to the morphological basis of cognitive impairment in elderly schizophrenics. In contrast to previous findings, recent studies have found no increased
Meta-analysis of postmortem studies of Alzheimer's disease-like neuropathology in schizophrenia.
Suggestions that cerebral plaques and neurofibrillary tangles are more common in schizophrenia in association with neuroleptic treatment were not supported and it was found that Alzheimer's disease-like neuropathology was not found in patients with schizophrenia.
Brain abnormality in schizophrenia
Several brain structures in schizophrenia are affected to a greater extent than expected from overall reductions in brain volume, and substantial reductions were also evident in the amygdala and hippocampus.
Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging : A meta-analytic study
Schizophrenia is associated with a bilateral volumetric reduction of the hippocampus and probably of the amygdala as well, which reinforces the importance of the medial temporal region in schizophrenia and is consistent with frequently reported memory deficits in these patients.
Recent advances in defining the neuropathology of schizophrenia
Six broad areas of neuropathological investigation into schizophrenia are summarized and discussed and a general lack of neurodegenerative disease lesions or ongoing astrocytosis that would indicate post-maturational neural injury is found.