Meta-analysis of association between genetic variants in COMT and schizophrenia: An update

@article{Okochi2009MetaanalysisOA,
  title={Meta-analysis of association between genetic variants in COMT and schizophrenia: An update},
  author={Tomo Okochi and Masashi Ikeda and Taro Kishi and Kunihiro Kawashima and Yoko Kinoshita and Tsuyoshi Kitajima and Yoshio Yamanouchi and Makoto Tomita and Toshiya Inada and Norio Ozaki and Nakao Iwata},
  journal={Schizophrenia Research},
  year={2009},
  volume={110},
  pages={140-148}
}
A common functional polymorphism, Val108/158Met (rs4680), and haplotypes rs737865-rs4680-rs165599 in the Catechol-O-methyltransferase gene (COMT) have been extensively examined for association to schizophrenia; however, results of replication studies have been inconsistent. The aim of this study was to comprehensively evaluate the genetic risk of COMT for schizophrenia. First, we performed a mutation scan to detect the existence of potent functional variants in the 5'-flanking and exon regions… Expand
HapMap tag-SNP analysis confirms a role for COMT in schizophrenia risk and reveals a novel association
TLDR
It is confirmed that COMT is a good candidate for schizophrenia risk, by replicating the association with rs4680 and identifying a novel SNP association. Expand
No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population
TLDR
The results suggest no significant association between the selected functional polymorphisms of COMT or MTHFR in Korean schizophrenia subjects, and further studies are required to confirm the findings in a larger number of subjects. Expand
Association between COMT gene rs165599 SNP and schizophrenia: A meta-analysis of case-control studies.
TLDR
The COMT gene rs165599 SNP does not appear to be a single-risk factor for schizophrenia, and although the subgroup analyzes reduced the heterogeneity, no association was obtained. Expand
No association of catechol-O-methyltransferase (COMT) gene haplotypes in patients with schizophrenia in a Turkish sample
TLDR
ComT rs2075507, rs4680, rs165599 SNPs and haplotypes do not appear to be risk factors for schizophrenia in this population of schizophrenic patients and controls. Expand
Association of functional polymorphisms in 3′-untranslated regions of COMT, DISC1, and DTNBP1 with schizophrenia: a meta-analysis
TLDR
This meta-analysis indicated that rs3737597 of DISC1 was significantly associated with schizophrenia in Europeans, and it can be suggested as an ethnic-specific risk genetic factor. Expand
Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new data and meta-analysis.
TLDR
The COMT functional polymorphism rs4680 contributes to schizophrenia genetic susceptibility under an overdominant model, indicating that both too high and too low levels of dopamine signalling may be risk factors. Expand
Association study between the rs165599 catechol-O-methyltransferase genetic polymorphism and schizophrenia in a Brazilian sample.
TLDR
In the sample studied, there was no evidence of any association between schizophrenia and rs165599 (A/G) polymorphism in the non-coding region 3' of the COMT gene. Expand
No association of catechol-O-methyltransferase polymorphisms with schizophrenia in the Han Chinese population.
TLDR
The results do not support the association of COMT with SZ in the Han Chinese population. Expand
Association of MB-COMT polymorphisms with schizophrenia-susceptibility and symptom severity in an African cohort
TLDR
The data generated by this study indicate that genetic variation of MB-COMT could be associated with schizophrenia and negative symptom severity in the Xhosa population and may therefore be one of the genomic loci contributing towards the disorder in the South African community. Expand
Serotonin 6 receptor gene and mood disorders: Case–control study and meta-analysis
TLDR
It is found that there is no association involving polymorphism and mood disorder in the Japanese population, and it will be necessary to conduct a further study about the relationship between this receptor and mood disorders in the future. Expand
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