Meta-analysis of Tpeak-Tend and Tpeak-Tend/QT ratio for risk stratification in congenital long QT syndrome.

@article{Tse2018MetaanalysisOT,
  title={Meta-analysis of Tpeak-Tend and Tpeak-Tend/QT ratio for risk stratification in congenital long QT syndrome.},
  author={Gary Tse and Mengqi Gong and Lei Meng and Cheuk Wai Wong and Stamatis Panagiotis Georgopoulos and George Bazoukis and Martin C. S. Wong and Konstantinos P. Letsas and Vassilios S Vassiliou and Yunlong Xia and Adrian M Baranchuk and Gan-xin Yan and Tong Liu},
  journal={Journal of electrocardiology},
  year={2018},
  volume={51 3},
  pages={
          396-401
        }
}
BACKGROUND AND OBJECTIVES Congenital long QT syndrome (LQTS) predisposes affected individuals to ventricular tachycardia/fibrillation (VF/VF), potentially resulting in sudden cardiac death. The Tpeak-Tend interval and the Tpeak-Tend/QT ratio, electrocardiographic markers of dispersion of ventricular repolarization, were proposed for risk stratification but their predictive values in LQTS have been controversial. A systematic review and meta-analysis was conducted to examine the value of Tpeak… Expand
Predictive Value of Tpeak – Tend Indices for Adverse Outcomes in Acquired QT Prolongation: A Meta-Analysis
TLDR
Tpeak – Tend interval and T peak – Tend/QT ratio were higher in patients with acquired QT prolongation suffering from torsade de pointes compared to those who did not, suggesting that these repolarization indices may provide additional predictive value for identifying high-risk individuals. Expand
Territory-Wide Chinese Cohort of Long QT Syndrome: Random Survival Forest and Cox Analyses
TLDR
Effective risk stratification in congenital LQTS can be achieved by clinical history, electrocardiographic indices, and different investigation results, irrespective of underlying genetic defects, a machine learning approach using RSF can improve risk prediction over traditional Cox regression models. Expand
T-Wave Indices and Atherosclerosis
TLDR
This review provides a comprehensive overview on how Tpeak-Tend is altered in different atherosclerotic conditions such as hypertension, stable coronary artery disease, acute coronary obstruction, and coronary slow flow as well as inflammatory diseases affecting the arterial tree. Expand
Electrocardiographic conduction and repolarization markers associated with sudden cardiac death: moving along the electrocardiography waveform.
TLDR
A review of novel ECG indices including ventricular ectopic QRS interval, the f99 index and EntropyXQT, which integrates mathematical and physical calculations for determining the risk markers, seeks to encapsulate the development of old and new ECG markers along with their associated utility and shortcomings in clinical practice. Expand
The ECG Characteristics of Patients With Isolated Hypomagnesemia
TLDR
In patients with isolated hypomagnesemia, P wave duration, QTc, Tpec, and Tpe/QT ratio suggesting atrial depolarization and ventricular repolarization dispersion were significantly increased compared with normal magnesium levels in the same patients after restoration to normal levels is suggested. Expand
Mechanisms of premature ventricular complexes caused by QT prolongation.
TLDR
This study investigates the genesis of PVCs using computer simulations with 8 different ventricular action potential models of various species and classifies PVCs as arising from two distinct mechanisms: repolarization gradient (RG)-induced PVCs and phase-2 EAD- induced PVCs. Expand
A novel prediction model for risk stratification in patients with a type 1 Brugada ECG pattern.
TLDR
The BRS score is a simple bed-side tool with high predictive accuracy, for risk stratification of patients with a Brugada Type 1 ECG pattern and Prospective validation of the prediction model is necessary before this score can be implemented in clinical practice. Expand
Association of QT dispersion with mortality and arrhythmic events—A meta‐analysis of observational studies
TLDR
The aim of this meta‐analysis is to indicate whether increased QT dispersion (QTd) is associated with fatal and nonfatal outcomes in patients with CHD and/or HF. Expand
QT interval and repolarization dispersion changes during the administration of hydroxychloroquine/chloroquine with/without azithromycin in early COVID 19 pandemic: A prospective observational study from two academic hospitals in Indonesia
TLDR
This study aimed to investigate QTc interval and ventricular repolarization dispersion changes, as markers of arrhythmia risks, after HCQ/CQ administration with/without azithromycin (AZT) during COVID‐19 pandemic. Expand
Channelopathies – An update 2018
TLDR
The knowledge on channelopathies is updated by briefly summarizing the literature, with specific emphasis on Brugada syndrome, CPVT and LQTS. Expand
...
1
2
...

References

SHOWING 1-10 OF 71 REFERENCES
The Tpeak - Tend interval as an electrocardiographic risk marker of arrhythmic and mortality outcomes: A systematic review and meta-analysis.
TLDR
The Tpeak - Tend interval is a useful risk stratification tool in different diseases and in the general population. Expand
Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome.
TLDR
This study demonstrates significant correlation between previous events, QTc >460 ms in V2, Tp-e, and T p-e dispersion and occurrence of life-threatening arrhythmic events, suggesting that these parameters may be useful in risk stratification of patients with the Brugada syndrome. Expand
Tpeak-Tend interval and Tpeak-Tend/QT ratio in patients with Brugada syndrome.
TLDR
Assessment of the Tpeak-Tend intervals or the TpTe/QT ratio in lead V1 is potentially useful as a non-invasive risk marker for BrS patients with life-threatening arrhythmias. Expand
Novel arrhythmic risk markers incorporating QRS dispersion: QRSd × (Tpeak − Tend)/QRS and QRSd × (Tpeak − Tend)/(QT × QRS)
  • G. Tse, B. Yan
  • Medicine
  • Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
  • 2017
TLDR
Two novel indices are proposed that may have a higher accuracy in risk stratification and have the potential of having superior predictive values than ventricular repolarization markers such as QTc, QTd, T peak − Tend, or (Tpeak − Tend)/QT ratio. Expand
Meta-analysis of Fragmented QRS as an Electrocardiographic Predictor for Arrhythmic Events in Patients with Brugada Syndrome
TLDR
It was showed that BrS patients with fQRS are at high risk for future arrhythmic events, and the presence of f QRS warrants prospective evaluation as valid arrhythmogenic risk marker in BrS. Expand
Assessment of QT dispersion in symptomatic patients with congenital long QT syndromes.
TLDR
Comparing patients with frequent and those with infrequent symptoms, there was no difference in QT or QTc dispersion either off treatment or during therapy with beta-blocking agents. Expand
(Tpeak - Tend)/QRS and (Tpeak - Tend)/(QT × QRS): novel markers for predicting arrhythmic risk in the Brugada syndrome.
  • G. Tse
  • Medicine
  • Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • 2017
TLDR
The interval from the peak to the end of the electrocardiographic T wave (T peak − Tend) and (Tpeak − Tend)/QT ratio, were strong risk markers for Brugada patients with life-threatening ventricular arrhythmias. Expand
Novel conduction-repolarization indices for the stratification of arrhythmic risk
  • G. Tse
  • Medicine
  • Journal of geriatric cardiology : JGC
  • 2016
TLDR
Several indices have been devised for SCD risk stratification, mainly focusing on ventricular repolarization, which is reflected by the QT interval on the electrocardiogram, including QT intervals corrected for heart rate, QT dispersion, and QT ratio. Expand
High prevalence of early repolarization in short QT syndrome.
TLDR
Early repolarization may be useful in identifying risk of cardiac events in patients with SQTS and was associated with arrhythmic events in multivariate models. Expand
Exercise Stress Test Amplifies Genotype-Phenotype Correlation in the LQT1 and LQT2 Forms of the Long-QT Syndrome
TLDR
Tpe interval increases during exercise in L QT1 but not in LQT2, which may partially account for the finding that fatal cardiac events in LqT1 are more often associated with exercise. Expand
...
1
2
3
4
5
...