Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases

@article{Tao2010MetaanalysisOT,
  title={Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases},
  author={Jin-Hui Tao and Yan-feng Zou and Xiao-Liang Feng and Jing Li and Fang Wang and Fan-Ming Pan and Dong-qing Ye},
  journal={Molecular Biology Reports},
  year={2010},
  volume={38},
  pages={4663-4672}
}
The aim of our meta-analysis was to quantitatively summarize the association of TYK2 gene polymorphisms with autoimmune and inflammatory diseases. 11 studies that included data from 21497 cases and 22647 controls were identified. OR was used as a measure of the effect of the association in a fixed/random effect model. Meta-analysis was performed for six TYK2 gene polymorphisms (rs34536443, rs2304256, rs280523, rs280519, rs12720270 and rs12720356). Significant association was found in rs34536443… CONTINUE READING