Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2

@inproceedings{Guilhamon2013MetaanalysisOI,
  title={Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2},
  author={Paul Guilhamon and Malihe Eskandarpour and Dina Halai and Gareth A. Wilson and Andrew Feber and Andrew E. Teschendorff and Valent{\'i} G{\'o}mez and Alexander Hergovich and Roberto Tirabosco and M. Fernanda Amary and Daniel Baumhoer and Gernot Jundt and Mark T. Ross and Adrienne M Flanagan and Stephan Beck},
  booktitle={Nature communications},
  year={2013}
}
Isocitrate dehydrogenase (IDH) genes 1 and 2 are frequently mutated in acute myeloid leukaemia (AML), low-grade glioma, cholangiocarcinoma (CC) and chondrosarcoma (CS). For AML, low-grade glioma and CC, mutant IDH status is associated with a DNA hypermethylation phenotype, implicating altered epigenome dynamics in the aetiology of these cancers. Here we show that the IDH variants in CS are also associated with a hypermethylation phenotype and display increased production of the oncometabolite 2… CONTINUE READING

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