Meta-analysis of Egg Consumption and Risk of Coronary Heart Disease and Stroke

@article{Alexander2016MetaanalysisOE,
  title={Meta-analysis of Egg Consumption and Risk of Coronary Heart Disease and Stroke},
  author={Dominik D. Alexander and Paula E. Miller and Ashley J. Vargas and Douglas L. Weed and Sarah S. Cohen},
  journal={Journal of the American College of Nutrition},
  year={2016},
  volume={35},
  pages={704 - 716}
}
The possible relationship between dietary cholesterol and cardiac outcomes has been scrutinized for decades. [] Key Method A comprehensive literature search was conducted through August 2015 to identify prospective cohort studies that reported risk estimates for egg consumption in association with CHD or stroke. Random-effects meta-analysis was used to generate summary relative risk estimates (SRREs) for high vs low intake and stratified intake dose-response analyses.
Egg consumption and cardiovascular risk: a dose–response meta-analysis of prospective cohort studies
TLDR
There is no conclusive evidence on the role of egg in CVD risk, despite the fact that higher quality studies are warranted to obtain stronger evidence for a possible protection of CVD associated with moderate weekly egg consumption compared to no intake; equally, future studies may strengthen the evidence for increased heart failure risk associated with high regular egg consumption.
Egg Consumption and Stroke Risk: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies
TLDR
The evidence from this meta-analysis showed that a J-shaped association exists between egg consumption and stroke risk and that geographic location significantly modified the effect of egg consumption on stroke risk.
Cholesterol and Egg Intakes, and Risk of Hypertension in a Large Prospective Cohort of French Women
TLDR
Egg and cholesterol intakes were associated with a higher risk of hypertension in French women, a major risk factor for cardiovascular disease, and merit further investigation in other populations.
Egg Consumption and Coronary Artery Disease: A Nice Knockdown Argument
TLDR
E egg consumption is independently associated with low incidence/mortality of CAD, which may be derived from the comparisons of the fifth versus first quintile egg consumption.
Egg consumption, cholesterol intake, and risk of incident stroke in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.
TLDR
Neither egg nor cholesterol intakes were associated with stroke risk in this cohort, regardless of apoE phenotype, but there were no associations with systolic blood pressure or with cholesterol intake.
Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults
TLDR
Among Chinese adults, a moderate level of egg consumption (up to <1 egg/day) was significantly associated with lower risk of CVD, largely independent of other risk factors.
Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality
TLDR
Among US adults, higher consumption of dietary cholesterol or eggs was significantly associated with higher risk of incident CVD and all-cause mortality in a dose-response manner and should be considered in the development of dietary guidelines and updates.
Egg and cholesterol consumption and mortality from cardiovascular and different causes in the United States: A population-based cohort study.
TLDR
Limiting cholesterol intake and replacing whole eggs with egg whites/substitutes or other alternative protein sources for facilitating cardiovascular health and long-term survival are suggested.
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References

SHOWING 1-10 OF 50 REFERENCES
Egg consumption in relation to cardiovascular disease and mortality: the Physicians' Health Study.
TLDR
Infrequent egg consumption does not seem to influence the risk of CVD in male physicians, and egg consumption was positively related to mortality, more strongly so in diabetic subjects, in the study population.
Egg consumption and risk of coronary heart disease and stroke: dose-response meta-analysis of prospective cohort studies
TLDR
Higher consumption of eggs (up to one egg per day) is not associated with increased risk of coronary heart disease or stroke, and the increasedrisk of coronaryHeart disease among diabetic patients and reduced risk of hemorrhagic stroke associated with higher egg consumption in subgroup analyses warrant further studies.
Egg consumption in relation to risk of cardiovascular disease and diabetes: a systematic review and meta-analysis.
TLDR
This meta-analysis suggests that egg consumption is not associated with the risk of CVD and cardiac mortality in the general population, however, egg consumption may be associated with an increased incidence of type 2 diabetes among the generalpopulation and CVD comorbidity among diabetic patients.
Egg consumption and cardiovascular disease among diabetic individuals: a systematic review of the literature
TLDR
Differences in study design, T2DM status, exposure measurement, subject age, control for confounders and follow-up time present significant challenges for conducting a meta-analysis of the relationship between egg consumption and cardiovascular disease risks among type II diabetes mellitus individuals and nondiabetic subjects.
Regular egg consumption does not increase the risk of stroke and cardiovascular diseases.
TLDR
Consumption of greater than 6 eggs per week (average of 1 egg or greater per day) does not increase the risk of stroke and ischemic stroke, and the increased risk of coronary artery disease associated with higher egg consumption among diabetics warrants further investigations.
Egg consumption and CHD and stroke mortality: a prospective study of US adults
TLDR
The relationship between egg consumption and CHD and stroke mortality using the Third National Health and Nutrition Examination Survey 1988–1994 and follow-up survey did not find a significant positive association and increased risk of mortality from CHD or stroke in the US population.
Egg consumption and risk of cardiovascular disease in the SUN Project
TLDR
No association was found between egg consumption and the incidence of CVD after adjusting for age, sex, total energy intake, adherence to the Mediterranean food pattern and other cardiovascular risk factors.
Egg consumption and risk of type 2 diabetes: a meta-analysis of prospective studies.
TLDR
A meta-analysis of published prospective cohort studies shows no relation between infrequent egg consumption and DM risk but suggests a modest elevated risk of DM with ≥3 eggs/wk that is restricted to US studies.
A prospective study of egg consumption and risk of cardiovascular disease in men and women.
TLDR
It is suggested that consumption of up to 1 egg per day is unlikely to have substantial overall impact on the risk of CHD or stroke among healthy men and women.
Egg consumption and carotid atherosclerosis in the Northern Manhattan study.
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