Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population

@article{Okada2012MetaanalysisIN,
  title={Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population},
  author={Yukinori Okada and Chikashi Terao and Katsunori Ikari and Yuta Kochi and Koichiro Ohmura and Akari Suzuki and Takahisa Kawaguchi and Eli Stahl and Fina A. S. Kurreeman and Nao Nishida and Hiroko Ohmiya and Keiko Myouzen and Meiko Takahashi and Tetsuji Sawada and Yuichi Nishioka and Masao Yukioka and Tsukasa Matsubara and Shigeyuki Wakitani and Ryota Teshima and Shigeto Tohma and Kiyoshi Takasugi and Kota Shimada and Akira Murasawa and Shigeru Honjo and Keitaro Matsuo and Hideo Tanaka and Kazuo Tajima and Taku Suzuki and Takuji Iwamoto and Yoshiya Kawamura and Hisashi Tanii and Yuji Okazaki and Tsukasa Sasaki and Peter K. Gregersen and Leonid Padyukov and Jane Worthington and Katherine Anne Siminovitch and Mark Lathrop and Atsuo Taniguchi and Atsushi Takahashi and Katsushi Tokunaga and Michiaki Kubo and Yusuke Nakamura and Naoyuki Kamatani and Tsuneyo Mimori and Robert M. Plenge and Hisashi Yamanaka and Shigeki Momohara and Ryo Yamada and Fumihiko Matsuda and Kazuhiko Yamamoto},
  journal={Nature Genetics},
  year={2012},
  volume={44},
  pages={511-516}
}
Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese population including 4,074 individuals with rheumatoid arthritis (cases) and 16,891 controls, followed by a replication in 5,277 rheumatoid arthritis cases and 21,684 controls. Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10−8, including B3GNT2, ANXA3, CSF2, CD83… CONTINUE READING
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