Meta-analysis identifies four new loci associated with testicular germ cell tumor

  title={Meta-analysis identifies four new loci associated with testicular germ cell tumor},
  author={Charles Y. C. Chung and Peter A. Kanetsky and Zhaoming Wang and Michelle A. T. Hildebrandt and Roelof Koster and Rolf I. Skotheim and Christian Kratz and Clare Turnbull and Victoria K. Cortessis and Anne Cathrine Bakken and D Timothy Bishop and Michael Blaise Cook and Ralph Loren Erickson and Sophie D Fossa and Kevin B. Jacobs and Larissa A. Korde and Sigrid Marie Kraggerud and Ragnhild A. Lothe and Jennifer T Loud and Nazneen Rahman and Eila Curlee Skinner and Duncan C Thomas and Xifeng Wu and Meredith Yeager and Fredrick R Schumacher and Mark H Greene and Stephen M Schwartz and Katherine A McGlynn and Stephen J. Chanock and Katherine L Nathanson},
  booktitle={Nature Genetics},
We conducted a meta-analysis to identify new susceptibility loci for testicular germ cell tumor (TGCT). In the discovery phase, we analyzed 931 affected individuals and 1,975 controls from 3 genome-wide association studies (GWAS). We conducted replication in 6 independent sample sets comprising 3,211 affected individuals and 7,591 controls. In the combined analysis, risk of TGCT was significantly associated with markers at four previously unreported loci: 4q22.2 in HPGDS (per-allele odds ratio… CONTINUE READING
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