Meta-analysis discovery of tissue-specific DNA sequence motifs from mammalian gene expression data

@article{Huber2005MetaanalysisDO,
  title={Meta-analysis discovery of tissue-specific DNA sequence motifs from mammalian gene expression data},
  author={Bertrand R. Huber and Martha L. Bulyk},
  journal={BMC Bioinformatics},
  year={2005},
  volume={7},
  pages={229 - 229}
}
A key step in the regulation of gene expression is the sequence-specific binding of transcription factors (TFs) to their DNA recognition sites. However, elucidating TF binding site (TFBS) motifs in higher eukaryotes has been challenging, even when employing cross-species sequence conservation. We hypothesized that for human and mouse, many orthologous genes expressed in a similarly tissue-specific manner in both human and mouse gene expression data, are likely to be co-regulated by orthologous… CONTINUE READING