Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.

@article{Jun2010MetaanalysisCC,
  title={Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.},
  author={Gyungah Jun and Adam C Naj and Gary W. Beecham and Li-San Wang and Jacqueline Buros and Paul J. Gallins and Joseph D. Buxbaum and Nil{\"u}fer Ertekin-Taner and M Daniele Fallin and Robert P Friedland and Rivka Inzelberg and Patricia Kramer and Ekaterina A. Rogaeva and Peter St George-Hyslop and Laura B. Cantwell and Beth A. Dombroski and Andrew J. Saykin and Eric M. Reiman and David A. Bennett and John C. Morris and Kathryn L. Lunetta and Eden R. Martin and Thomas J. Montine and Alison M. Goate and Deborah Blacker and Debby W. Tsuang and Duane L. Beekly and L. Adrienne Cupples and Hakon Hakonarson and Walter Kukull and Tatiana Foroud and Jonathan Haines and Richard Mayeux and Lindsay A. Farrer and Margaret A. Pericak-Vance and Gerard D. Schellenberg},
  journal={Archives of neurology},
  year={2010},
  volume={67 12},
  pages={1473-84}
}
OBJECTIVES To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes. DESIGN Association study of AD and CLU, PICALM, CR1, and APOE genotypes. SETTING Academic research institutions in the United States, Canada, and Israel. PARTICIPANTS Seven thousand seventy cases with AD, 3055 with autopsies, and 8169 elderly cognitively normal controls, 1092 with… CONTINUE READING
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