Meta-analysis and systematic review of procalcitonin-guided therapy in respiratory tract infections.

@article{Li2011MetaanalysisAS,
  title={Meta-analysis and systematic review of procalcitonin-guided therapy in respiratory tract infections.},
  author={Hui Li and Yi-feng Luo and Timothy S. Blackwell and Can-mao Xie},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 12},
  pages={5900-6}
}
Circulating procalcitonin (PCT) is a biomarker that can be used in diagnosing bacterial infections. We performed a quantitative meta-analysis of available randomized controlled trials to determine whether antibiotic therapy based on PCT measurements alters clinical outcomes and antibiotic use in patients with lower respiratory tract infections. We identified studies through MEDLINE (1996 to 2010), the ISI Web of Knowledge (1996 to 2010), and Ovid. Studies that met our criteria were prospective… CONTINUE READING
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