Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders

  title={Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders},
  author={L. Tak and A. Cleare and J. Ormel and A. Manoharan and J. Rosmalen},
  journal={Biological Psychology},
  • L. Tak, A. Cleare, +2 authors J. Rosmalen
  • Published 2011
  • Medicine, Psychology
  • Biological Psychology
  • Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is the most investigated biological risk marker in functional somatic disorders (FSDs), such as chronic fatigue syndrome (CFS), fibromyalgia (FM), and irritable bowel syndrome (IBS). Our aim was to assess whether there is an association between basal hypocortisolism and FSD and to identify potential moderators of this association. Meta-analysis on 85 studies revealed that although basal cortisol levels were generally lower in FSD… CONTINUE READING
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