Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders

@article{Tak2011MetaanalysisAM,
  title={Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders},
  author={Lineke M. Tak and Anthony J. Cleare and Johan Ormel and Andiappan Manoharan and Iris C. Kok and Simon Wessely and Judith G. M. Rosmalen},
  journal={Biological Psychology},
  year={2011},
  volume={87},
  pages={183-194}
}
Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is the most investigated biological risk marker in functional somatic disorders (FSDs), such as chronic fatigue syndrome (CFS), fibromyalgia (FM), and irritable bowel syndrome (IBS). Our aim was to assess whether there is an association between basal hypocortisolism and FSD and to identify potential moderators of this association. Meta-analysis on 85 studies revealed that although basal cortisol levels were generally lower in FSD… Expand
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