Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths.

@article{Salpeter2006MetaanalysisEO,
  title={Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths.},
  author={Shelley R. Salpeter and Nicholas S. Buckley and Thomas M. Ormiston and Edwin Salpeter},
  journal={Annals of internal medicine},
  year={2006},
  volume={144 12},
  pages={904-12}
}
Context Long-acting -agonists may help improve asthma symptoms, but they also may increase risks for adverse outcomes. Contribution This meta-analysis summarizes data from 19 randomized, placebo-controlled trials involving 33826 participants with asthma. Compared with placebo, long-acting -agonists increased severe exacerbations requiring hospitalization (odds ratio, 2.6 [95% CI, 1.6 to 4.3]), life-threatening exacerbations (odds ratio, 1.8 [CI, 1.1 to 2.9]), and asthma-related deaths (odds… CONTINUE READING

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