Meta-analysis: Diagnostic Accuracy of AntiCyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis

@article{Nishimura2007MetaanalysisDA,
  title={Meta-analysis: Diagnostic Accuracy of AntiCyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis},
  author={Kunihiro Nishimura and Daisuke Sugiyama and Yoshinori Kogata and Goh Tsuji and Takashi Nakazawa and Seiji Kawano and Katsuyasu Saigo and Akio Morinobu and Masahiro Koshiba and Karen M Kuntz and Isao Kamae and Shunichi Kumagai},
  journal={Annals of Internal Medicine},
  year={2007},
  volume={146},
  pages={797-808}
}
Context Are autoantibodies against cyclic citrullinated peptide (CCP) better serum markers for rheumatoid arthritis than rheumatoid factor (RF)? Contribution This meta-analysis of 86 studies found that the positive likelihood ratio for anti-CCP antibody was greater than that for IgM RF for identifying patients with rheumatoid arthritis (12.5 vs. 4.9). Sensitivity was similar for the 2 tests, although specificity of anti-CCP antibody (95%) was higher than specificity of IgM RF (85%). Cautions… 
Likelihood ratios as a function of antibody concentration for anti-cyclic citrullinated peptide antibodies and rheumatoid factor.
TLDR
In the present letter, the likelihood ratios for anti-CCP and RF are illustrated to show how likelihood ratios were calculated based on a single cut-off value.
Diagnostic utility of anti-citrullinated protein antibody and its comparison with rheumatoid factor in rheumatoid arthritis.
TLDR
Assessment of medical records of patients with complaints of muscular or joint pains found anti-CCP is useful for the diagnosis of RA due to its higher specificity as compared to RF and can predict disease severity.
Diagnostic performance of anti-citrullinated peptide antibodies for the diagnosis of rheumatoid arthritis: the relevance of likelihood ratios
TLDR
A value of anti-CCP2 >15 U/mL is associated with an increase in the likelihood of RA disease, and the cut-off value of 2.8 U/ mL has the highest diagnostic accuracy.
A Comparative Assessment of the Diagnostic Value of Anti-cyclicCitrullinated Peptide Antibodies and Rheumatoid Factor in RheumatoidArthritis
TLDR
The sensitivity, specificity, positive predictive value and negative predictive value of anti-cyclic citrullinated peptide antibodies for diagnosing rheumatoid arthritis were 70.76%, 85.07%, 90%, and 59% respectively, while those for r heumatoid factor were 46.26%, 90.29%, 90, and 45% respectively.
The diagnostic utility of the anti-CCP antibody test is no better than rheumatoid factor in South Africans with early rheumatoid arthritis
TLDR
It is suggested that testing for aCCP is only cost-effective in the RF-negative patient in whom there is a strong clinical suspicion of RA, and the best specificity and PPV observed when both the a CCP and RF tests were positive.
Triple Positivity for Anti–Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti–Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis
TLDR
The aim of the present study was to investigate the value of combined antibody testing in relation to prediction and diagnosis of (early) RA.
Ethnic differences in the prognostic utility of rheumatoid factor isotypes and anticyclic citrullinated peptides in rheumatoid arthritis patients: a cross-sectional study
Abstract Objectives The prognostic significance of rheumatoid factor (RF) and anticyclic citrullinated peptide antibody (anti-CCP) in rheumatoid arthritis (RA) remains contentious due to the
Ethnic differences in the prognostic utility of rheumatoid factor isotypes and anticyclic citrullinated peptides in rheumatoid arthritis patients: a cross-sectional study
TLDR
RF, in particular, IgG and IgM, may be better prognosticators of severe disease in Chinese and Indian patients and there is variability in the phenotypic association of RF isotypes and anti-CCP in relation to disease severity of RA in the three ethnic groups.
Anti-cyclic citrullinated peptide testing for the diagnosis of rheumatoid arthritis and the quest for improved sensitivity and predictive value.
TLDR
Comparative studies of different anti–cyclic citrullinated peptide (anti–CCP) tests in patients from the Leiden Early Arthritis Clinic are presented, important for selecting the most clinically useful anti-CCP tests and for better understanding the role of autoantibodies to citruLLinated epitopes in the pathogenesis of rheumatoid arthritis (RA).
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References

SHOWING 1-10 OF 122 REFERENCES
Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors.
TLDR
With their excellent specificity, anti-CCP antibodies can be useful in establishing the diagnosis of RA, but IgM RF is a better predictor of disease severity.
Diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis.
TLDR
Positivity in the highly specific CCP ELISA supports the diagnosis of rheumatoid arthritis and the IgM-RF and the CCP assays are superior to other RF isotypes.
Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis.
TLDR
Anti-CCP antibody testing may be useful if performed concomitantly with RF assay to diagnose patients with suspected early RA.
Is Anti Cyclic citrullinated peptide a useful laboratory test for the diagnosis of rheumatoid arthritis?
TLDR
Anti-CCP is a useful laboratory marker to confirm the diagnosis of rheumatoid arthritis; it seems to be very important to differentiate patients with RA from those with HCV related arthritis.
Diagnostic value of anti-cyclic citrullinated Peptide antibody in patients with rheumatoid arthritis.
TLDR
A new modified anti-CCP antibody test had a moderate sensitivity but a high specificity in patients with RA and was found as a valuable supplement to diagnosis of RA.
Rheumatoid factor and antibodies to cyclic citrullinated Peptide differentiate rheumatoid arthritis from undifferentiated polyarthritis in patients with early arthritis.
TLDR
The criterion IgM-RF > 40 or anti-CCP > 50 is able to predict the diagnosis of RA in early arthritis patients with high specificity and acceptable sensitivity.
Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis.
TLDR
The presence either of anti-CCP antibodies and IgA RF or of the three markers appears to be useful in the diagnosis of RA, and their association with clinical signs of disease severity at the time of patient inclusion suggests their potential usefulness as markers for prognosis.
The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide.
TLDR
The anti-CCP ELISA might be very useful for diagnostic and therapeutic strategies in RA of recent onset and appears to be highly specific for RA, using prevalent RA and non-RA sera.
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