Meta-analysis: Diagnostic Accuracy of AntiCyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis

  title={Meta-analysis: Diagnostic Accuracy of AntiCyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis},
  author={K. Nishimura and D. Sugiyama and Y. Kogata and Goh Tsuji and Takashi Nakazawa and S. Kawano and Katsuyasu Saigo and A. Morinobu and M. Koshiba and K. Kuntz and I. Kamae and S. Kumagai},
  journal={Annals of Internal Medicine},
  • K. Nishimura, D. Sugiyama, +9 authors S. Kumagai
  • Published 2007
  • Medicine
  • Annals of Internal Medicine
  • Context Are autoantibodies against cyclic citrullinated peptide (CCP) better serum markers for rheumatoid arthritis than rheumatoid factor (RF)? Contribution This meta-analysis of 86 studies found that the positive likelihood ratio for anti-CCP antibody was greater than that for IgM RF for identifying patients with rheumatoid arthritis (12.5 vs. 4.9). Sensitivity was similar for the 2 tests, although specificity of anti-CCP antibody (95%) was higher than specificity of IgM RF (85%). Cautions… CONTINUE READING
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