Meta-analysis: Chondroitin for Osteoarthritis of the Knee or Hip

@article{Reichenbach2007MetaanalysisCF,
  title={Meta-analysis: Chondroitin for Osteoarthritis of the Knee or Hip},
  author={Stephan Reichenbach and Rebekka Sterchi and Martin Scherer and Sven Trelle and Elizabeth Brgi and Ulrich Brgi and P. A. Dieppe and Peter Jni},
  journal={Annals of Internal Medicine},
  year={2007},
  volume={146},
  pages={580-590}
}
Context People sometimes use chondroitin preparations to prevent hip or knee damage and pain. Contribution This systematic review summarized data from 20 trials that compared the effects of chondroitin with either placebo or no treatment in patients with hip or knee osteoarthritis. Recent high-quality trials showed chondroitin had minimal or no effect on joint pain. Effects on joint space were inconclusive. Few adverse events were reported. Implication Chondroitin probably does not prevent or… 
Glucosamine and chondroitin for the treatment of osteoarthritis
TLDR
There is currently no convincing information for the efficacy of GL and CH on OA, and the clinical efficacy and safety after the use of these supplements is investigated.
Chondroitin for osteoarthritis.
TLDR
The benefit and harm of oral chondroitin for treating osteoarthritis compared with placebo or a comparator oral medication including, but not limited to, nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics, opioids, and glucosamine or other "herbal" medications are evaluated.
Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis
TLDR
Compared with placebo, glucosamine, chondroitin, and their combination do not reduce joint pain or have an impact on narrowing of joint space and health authorities and health insurers should not cover the costs.
Chondroitin sulphate for symptomatic osteoarthritis: critical appraisal of meta-analyses
TLDR
Data provided by meta-analyses indicate that CS has a slight to moderate efficacy in the symptomatic treatment of OA, with an excellent safety profile.
[Nutraceuticals in therapy of knee osteoarthritis: orthopaedic view].
TLDR
Similar to rheumatologists, orthopaedic surgeons also find it difficult to identify candidates suitable for a particular type of therapy, except indication for TKR, where nutraceuticals are still considered part of clinical practice.
Pharmacologic Agents for Knee Articular Cartilage Injury and Disease
Pharmacologic management for articular cartilage injury and osteoarthritis (OA) should always be considered as supplemental to conservative approaches related to physical and/or rehabilitative
Osteoarthritis: Diagnosis and Treatment
TLDR
Patients with chronic pain and disability despite maximal medical therapy should begin with acetaminophen and step up to nonsteroidal anti-inflammatory drugs.
The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial.
TLDR
At 2 years, no treatment achieved a predefined threshold of clinically important difference in JSW loss as compared with placebo, however, knees with K/L grade 2 radiographic OA appeared to have the greatest potential for modification by these treatments.
Doxycycline for osteoarthritis of the knee or hip.
TLDR
It is confirmed that the symptomatic benefit of doxycycline is minimal to non-existent, while the small benefit in terms of joint space narrowing is of questionable clinical relevance and outweighed by safety problems.
...
...

References

SHOWING 1-10 OF 63 REFERENCES
Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.
TLDR
Evaluation of benefit of glucosamine and chondroitin preparations for OA symptoms using meta-analysis combined with systematic quality assessment of clinical trials of these preparations in knee and/or hip OA suggests some degree of efficacy appears probable for these preparations.
Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.
TLDR
This study demonstrates the structural efficacy of glucosamine and indistinguishable symptomatic efficacies for both compounds in knee osteoarthritis and further studies are needed to investigate the relationship among time, dose, patient baseline characteristics, and structural efficacy for an accurate, disease-modifying characterization of these 2 compounds.
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.
TLDR
Exploratory analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain, and the efficacy and safety of these treatments as a treatment for knee pain from osteoarthritis are evaluated.
Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: a randomized, controlled trial.
TLDR
While there was no significant symptomatic effect in this study, long-term treatment with CS may retard radiographic progression in patients with OA of the knee, but the clinical relevance of the observed structural results has to be further evaluated, and further studies are needed to confirm the structural effects of CS.
A metaanalysis of chondroitin sulfate in the treatment of osteoarthritis.
TLDR
CS may be useful in OA, but further investigations in larger cohorts of patients for longer time periods are needed to prove its usefulness as a symptom modifying drug in Oa.
[Anti-arthrosis treatments: efficacy and tolerance of chondroitin sulfates (CS 4&6)].
TLDR
This study suggests that chondroitin sulfates act as structure modulators as shown by the improvement in the interarticular space visualized on the x-rays of patients treated with CS 4&6.
[Chondroitin sulfate in the treatment of gonarthrosis and coxarthrosis. 5-months result of a multicenter double-blind controlled prospective study using placebo].
TLDR
It is indicated that chondroitin sulfate is useful for the treatment of osteoarthritis, both as an agent slowly effective against symptoms and to reduce the need for NSAIDs.
Osteoarthritis: New Insights. Part 2: Treatment Approaches
TLDR
Although acetaminophen fails to adequately relieve pain in many patients, it merits a trial on the basis of its overall cost, efficacy, and toxicity profile and is derived from updated recommendations of the American College of Rheumatology for the treatment of osteoarthritis.
...
...