Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk.

@article{Lewis2006MetaanalysesOO,
  title={Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk.},
  author={Sarah Jayne Lewis and Roger M. Harbord and Ross D. Harris and George Davey Smith},
  journal={Journal of the National Cancer Institute},
  year={2006},
  volume={98 22},
  pages={
          1607-22
        }
}
BACKGROUND Evidence from case-control studies suggests that increasing dietary folate intake is associated with a reduced risk of breast cancer. However, large cohort studies have found no such association, and animal studies suggest that folate supplementation may promote tumorigenesis. We conducted a meta-analysis to summarize the available evidence from observational studies on this issue and a meta-analysis of the association between a common polymorphism in the 5,10… CONTINUE READING
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