Meta-Analysis on the Effects of Octreotide on Tumor Mass in Acromegaly

  title={Meta-Analysis on the Effects of Octreotide on Tumor Mass in Acromegaly},
  author={Andrea Giustina and Gherardo Mazziotti and Valter Torri and Maurizio Spinello and Irene C Floriani and Shlomo Melmed},
  booktitle={PloS one},
BACKGROUND The long-acting somatostatin analogue octreotide is used either as an adjuvant or primary therapy to lower growth hormone (GH) levels in patients with acromegaly and may also induce pituitary tumor shrinkage. OBJECTIVE We performed a meta-analysis to accurately assess the effect of octreotide on pituitary tumor shrinkage. DATA SOURCES A computerized Medline and Embase search was undertaken to identify potentially eligible studies. STUDY ELIGIBILITY CRITERIA Eligibility criteria… CONTINUE READING


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The efficacy of octreotide LAR as firstline therapy for patients with newly diagnosed acromegaly is independent of tumor extension: predictive factors of tumor and biochemical response

  • M Luque-Ramı́rez, GR Portoles, C Varela, R Albero, I Halperin
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