Meta-Analysis of the Use of Rescue Antiemetics Following PONV Prophylactic Failure with 5-HT3 Antagonist/Dexamethasone Versus Single-Agent Therapies

@article{Kovac2006MetaAnalysisOT,
  title={Meta-Analysis of the Use of Rescue Antiemetics Following PONV Prophylactic Failure with 5-HT3 Antagonist/Dexamethasone Versus Single-Agent Therapies},
  author={A. Kovac},
  journal={Annals of Pharmacotherapy},
  year={2006},
  volume={40},
  pages={873 - 887}
}
  • A. Kovac
  • Published 2006
  • Medicine
  • Annals of Pharmacotherapy
Objective: To assess the use of rescue antiemetic medication following 5-HT3 receptor antagonist (5-HT3RA) plus dexamethasone therapy versus monotherapy with a 5-HT3RA for prophylaxis of postoperative nausea and vomiting (PONV). Data Sources: Reports of randomized, controlled trials were identified via a MEDLINE search (1966–September 2005) using the key terms ondansetron, dolasetron, tropisetron, granisetron, 5-HT3, PONV, vomiting, emesis, and nausea. Study Selection and Data Extraction… Expand
Eliminating Postoperative Nausea and Vomiting in Outpatient Surgery with Multimodal Strategies including Low Doses of Nonsedating, Off-Patent Antiemetics: Is “Zero Tolerance“ Achievable?
TLDR
A “zero-tolerance” antiemetic algorithm for outpatients that involves routine prophylaxis by first avoiding volatile agents and opioids to the extent possible, using locoregional anesthesia, multimodal analgesia, and low doses of three nonsedating off-patent antiemetics is proposed. Expand
Randomized Double Blind Comparative Study Comparing Efficacy of Granisetron and Ondansetron for the Prophylactic Control of Postoperative Nausea and Vomiting in Patients Undergoing Middle Ear Surgery
TLDR
Grisetron is more efficacious and desirable drug than ondansetron for reducing the incidence of PONV in patients undergoing middle ear surgery and willingness to have the same prophylactic antiemetic drug in future was significantly high in patients receiving granisetron. Expand
Evaluation of granisetron as an antiemetic in patients undergoing abdominal hysterectomy under spinal anaesthesia
TLDR
Granisetron 2 Mg has better efficacy and safety profile than ondansetron 4 Mg and reduces PONV in strabismus repair, tonsillectomy, and general surgeries, it has less side effects as compared to ondANSetron. Expand
Mechanisms Underlying Postoperative Nausea and Vomiting and Neurotransmitter Receptor Antagonist-Based Pharmacotherapy
TLDR
NK1 receptor antagonists, with their unique mechanism of action, are a particularly promising area of research as they appear to be efficacious in preventing PONV during both the early and the late postoperative periods. Expand
Current research on PONV/PDNV: Practical implications for today's pharmacist.
  • R. Ignoffo
  • Medicine
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2009
TLDR
Evidence from the Prospective Observational Study of Treatments, Outcomes, and Patterns of Care study indicates that the use of guideline recommended PONV and PDNV prophylactic treatments leads to improved outcomes. Expand
Propofol for the management of postoperative nausea and vomiting (PONV)
TLDR
The main objective of these series of investigations was to systematically determine the antiemetic effects of propofol and recommend how prop ofol should be used in clinical practice. Expand
Aprepitant vs. Multimodal Prophylaxis in the Prevention of Nausea and Vomiting following Extended‐Release Epidural Morphine
TLDR
The incidence of PONV following prophylactic aprepitant, a neurokinin‐1 antagonist, was compared with proPHylactic multimodal antiemetic therapy in patients receiving EREM for postoperative analgesia following unilateral primary total knee arthroplasty. Expand
Ondansetron for postoperative nausea and vomiting
TLDR
Understanding of patient-to-patient variability in the metabolism of ondansetron and the interaction of the different receptors in the nausea–vomiting neuroendocrine pathway may eventually greatly decrease the incidence of postoperative nausea and vomiting. Expand
Steroid kullanan supratentoryal kitle olgularinda intravenöz granisetron ve ondansetron uygulamalarinin postoperatif bulanti, kusma üzerine olan etkilerinin karşilaştirilmasi
TLDR
The aim of this study was to compare the efficacy of steroids or steroids combined with ondansetron and granisetron in patients undergoing intracranial surgery, and the existence of vomiting in Group 1 was significantly higher than Group 2 and Group 3. Expand
Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials
TLDR
DDIs can play significant roles in drugs’ cardiac safety, as evidenced by the provided examples, and PD components of DDIs should be accounted for as PK changes alone do not allow to fully explain the electrophysiological effects in clinic situations. Expand
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TLDR
It is concluded that there is no statistically significant difference in antiemetic efficacy or side effects profile when one of the 5-HT is combined with either droperidol or dexamethasone and that both combination regimens are significantly more effective than 5- HT alone. Expand
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