Meta-Analysis of the Use of Rescue Antiemetics Following PONV Prophylactic Failure with 5-HT3 Antagonist/Dexamethasone Versus Single-Agent Therapies

  title={Meta-Analysis of the Use of Rescue Antiemetics Following PONV Prophylactic Failure with 5-HT3 Antagonist/Dexamethasone Versus Single-Agent Therapies},
  author={Anthony L. Kovac},
  journal={Annals of Pharmacotherapy},
  pages={873 - 887}
  • A. Kovac
  • Published 1 May 2006
  • Medicine
  • Annals of Pharmacotherapy
Objective: To assess the use of rescue antiemetic medication following 5-HT3 receptor antagonist (5-HT3RA) plus dexamethasone therapy versus monotherapy with a 5-HT3RA for prophylaxis of postoperative nausea and vomiting (PONV). Data Sources: Reports of randomized, controlled trials were identified via a MEDLINE search (1966–September 2005) using the key terms ondansetron, dolasetron, tropisetron, granisetron, 5-HT3, PONV, vomiting, emesis, and nausea. Study Selection and Data Extraction… 

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