Meta-Analysis of Genome-Wide Scans for Human Adult Stature Identifies Novel Loci and Associations with Measures of Skeletal Frame Size

@inproceedings{Soranzo2009MetaAnalysisOG,
  title={Meta-Analysis of Genome-Wide Scans for Human Adult Stature Identifies Novel Loci and Associations with Measures of Skeletal Frame Size},
  author={Nicole Soranzo and Fernando Rivadeneira and Usha Chinappen-Horsley and Ida Malkina and J Brent Richards and Naomi Hammond and Lisette Stolk and Alexandra C. Nica and Michael Inouye and Albert Hofman and Jonathan P. Stephens and Eleanor Wheeler and Pascal A Arp and Rhian Gwilliam and P. Mila Jhamai and Simon Potter and Amy F. Chaney and Mohammed J. R. Ghori and Radhi Ravindrarajah and Sergey Ermakov and Karol Estrada and Huibert A. P. Pols and Frances M K Williams and Wendy L. Mcardle and Joyce B. J. van Meurs and Ruth J. F. Loos and Emmanouil T. Dermitzakis and Kourosh Ahmadi and Deborah J. Hart and Willem H Ouwehand and Nicholas J Wareham and In{\^e}s Barroso and Manjinder S. Sandhu and David P. Strachan and Gregory Livshits and Tim D. Spector and Andr{\'e} G. Uitterlinden and Panagiotis Deloukas},
  booktitle={PLoS genetics},
  year={2009}
}
Recent genome-wide (GW) scans have identified several independent loci affecting human stature, but their contribution through the different skeletal components of height is still poorly understood. We carried out a genome-wide scan in 12,611 participants, followed by replication in an additional 7,187 individuals, and identified 17 genomic regions with GW-significant association with height. Of these, two are entirely novel (rs11809207 in CATSPER4, combined P-value = 6.1x10(-8) and rs910316 in… CONTINUE READING

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