Meta-Analysis and Gene Set Enrichment Relative to ER Status Reveal Elevated Activity of MYC and E2F in the “Basal” Breast Cancer Subgroup

@article{Alles2009MetaAnalysisAG,
  title={Meta-Analysis and Gene Set Enrichment Relative to ER Status Reveal Elevated Activity of MYC and E2F in the “Basal” Breast Cancer Subgroup},
  author={Marie Chehani Alles and Margaret Gardiner-Garden and David J. Nott and Yixin Wang and John A. Foekens and Robert Lyndsay Sutherland and Elizabeth A. Musgrove and Christopher J Ormandy},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={516 - 525}
}
BACKGROUND Breast cancers lacking the estrogen receptor (ER) can be distinguished from other breast cancers on the basis of poor prognosis, high grade, distinctive histopathology and unique molecular signatures. These features further distinguish estrogen receptor negative (ER-) tumor subtypes, but targeted therapy is currently limited to tumors over-expressing the ErbB2 receptor. METHODOLOGY/PRINCIPAL FINDINGS To uncover the pathways against which future therapies could be developed we… CONTINUE READING
Highly Cited
This paper has 49 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2015
View 7 Excerpts
Highly Influenced

MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition

The Journal of experimental medicine • 2012
View 4 Excerpts
Highly Influenced