Corpus ID: 2488269

Meta-Analysis Effects of Intravenous and Oral Magnesium on Reducing Migraine : A Meta-analysis of Randomized Controlled Trials

@inproceedings{Chiu2016MetaAnalysisEO,
  title={Meta-Analysis Effects of Intravenous and Oral Magnesium on Reducing Migraine : A Meta-analysis of Randomized Controlled Trials},
  author={Hsiao-Yean Chiu and Tu-Hsueh Yeh and Yin-Cheng Huang and Pin-Yuan Chen},
  year={2016}
}
Results: A total of 21 studies were included. Of which, 11 studies investigated the effects of intravenous magnesium on acute migraine (948 participants) and 10 examined the effects of oral magnesium on migraine prophylaxis (789 participants). Intravenous magnesium significantly relieved acute migraine within 15 – 45 minutes, 120 minutes, and 24 hours after the initial infusion (Odd ratios [ORs] = 0.23, 0.20, and 0.25, respectively). Oral magnesium significantly alleviated the frequency and… Expand

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TLDR
High-dose oral magnesium appears to be effective in migraine prophylaxis and duration and intensity of attacks and the drug consumption per attack tended to decrease compared to placebo but failed to be significant. Expand
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The meta-analyses have failed to demonstrate a beneficial effect of intravenous magnesium in terms of reduction in pain relief in acute migraine in adults, showed no benefit in Terms of the need for rescue medication and in fact have shown that patients treated with magnesium were significantly more likely to report side-effects/adverse events. Expand
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TLDR
The migraine prophylactic effect of 10 mmol magnesium twice-daily has been evaluated in a multicentre, prospective, randomized, double-blind, placebo-controlled study, with no benefit with magnesium compared to placebo. Expand
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The data support the idea that magnesium sulphate can be used for the treatment of all symptoms in migraine with aura, or as an adjuvant therapy for associated symptoms in patients with migraine without aura. Expand
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TLDR
It is thought that magnesium is a beneficial agent in prophylaxis of migraine without aura and might work with both vascular and neurogenic mechanisms. Expand
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TLDR
The data suggest that the addition of magnesium to metoclopramide may attenuate the effectiveness of metoclipramide in relieving migraine, and countertherapeutic cerebral vasodilatation caused by magnesium is a plausible, although unproven, explanation for this finding. Expand
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Although patients receiving placebo required rescue medication more than the others, metoclopramide and magnesium have an analgesic effect similar to placebo in migraine attacks. Expand
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BACKGROUND There is controversy about the efficacy of currently used treatment modalities to alleviate migraine headaches. OBJECTIVE We aimed to evaluate and compare the effects of magnesiumExpand
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No benefit is found to using IV magnesium to treat patients with acute benign headache who present to the emergency department, and patients who received magnesium had significantly more side effects than did those in the placebo group. Expand
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TLDR
It was determined that intravenous prochlorperazine is highly effective in the treatment of headache and magnesium is moderately effective. Expand
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