Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

  title={Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality},
  author={E. Miller and R. Pastor-Barriuso and D. Dalal and R. Riemersma and L. Appel and E. Guallar},
  journal={Annals of Internal Medicine},
  • E. Miller, R. Pastor-Barriuso, +3 authors E. Guallar
  • Published 2005
  • Medicine
  • Annals of Internal Medicine
  • Context Does vitamin E supplementation increase mortality in adults? Contribution This meta-analysis of 19 randomized, controlled trials involving more than 135000 participants found that high-dosage vitamin E supplementation (400 IU/d for at least 1 year) increased all-cause mortality. Benefits or harms of lower-dosage supplementation were unclear. Cautions Trials that tested high dosages involved adults with chronic diseases, and these findings may not be generalizable to healthy adults. Some… CONTINUE READING
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