Meta-Analysis: Does Garlic Intake Reduce Risk of Gastric Cancer?

@article{Kodali2015MetaAnalysisDG,
  title={Meta-Analysis: Does Garlic Intake Reduce Risk of Gastric Cancer?},
  author={Ramyasri Kodali and Guy D. Eslick},
  journal={Nutrition and Cancer},
  year={2015},
  volume={67},
  pages={1 - 11}
}
In the past 2 decades, various epidemiological studies investigated whether garlic can positively modify the risk of gastric cancer. Garlic contains numerous sulfide compounds, including diallyl trisulfide, which have anticarcinogenic properties. We conducted a meta-analysis to determine if garlic intake reduces the risk of gastric cancer. An electronic search of MEDLINE, PubMed, and EMBASE to June 2014 was completed. There were 14 case control studies, 2 randomized controlled studies, and 1… 

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References

SHOWING 1-10 OF 36 REFERENCES

An intervention study to prevent gastric cancer by micro-selenium and large dose of allitridum.

TLDR
The present study proves that large doses of allitridum and microdorse of selenium may effectively prevent gastric cancer, especially in men.

Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality.

TLDR
Garlic and vitamin treatments were associated with non-statistically significant reductions in gastric cancer incidence and mortality and vitamin treatment was associated with statistically significantly fewer deaths from gastric or esophageal cancer, a secondary endpoint.

Consumption of onions and a reduced risk of stomach carcinoma

TLDR
The Netherlands Cohort Study provides evidence for a strong inverse association between onion consumption and stomach carcinoma incidence and the consumption of leeks and the use of garlic supplements were not associated with stomach carcinomas risk.

The reliability of dietary history from the distant past.

TLDR
Assessing current diet to make inference about diet from the distant past does not yield more reliable estimates of past diet than does the retrospective dietary history, and the best estimate of diet from several years in the past may be derived directly from a retrospective Dietary history which focuses on that past period of time.

Salty Food Intake and Risk of Helicobacter pylori Infection

TLDR
Consumption of salty foods appears to increase the risk of H. pylori infection, which could be a marker of salty food intake or an intermediate risk factor in the etiologic sequence between salty food consumption and gastric cancer.

A meta-analysis of body mass index and esophageal and gastric cardia adenocarcinoma.

TLDR
Overweight and obesity are strongly related to EGCA, particularly to espophageal adenocarcinoma, as well as normo-weight subjects, using random-effects models.

Protective Effect of Allium Vegetables against Both Esophageal and Stomach Cancer: A Simultaneous Case‐referent Study of a High‐epidemic Area in Jiangsu Province, China

TLDR
The main results suggested that allium vegetables, like raw vegetables, may have an important protecting effect against not only stomach cancer, but also esophageal cancer.

A case‐control study of gastric cancer and diet in Italy

TLDR
It is indicated that dietary factors contribute to the regional variation of stomach cancer occurrence in Italy, and offer clues for further etiologic and prevention research.