Meta‐analysis of the efficacy of the acetonic kava‐kava extract WS®1490 in patients with non‐psychotic anxiety disorders

@article{Witte2005MetaanalysisOT,
  title={Meta‐analysis of the efficacy of the acetonic kava‐kava extract WS{\textregistered}1490 in patients with non‐psychotic anxiety disorders},
  author={S. Witte and D. Loew and W. Gaus},
  journal={Phytotherapy Research},
  year={2005},
  volume={19}
}
Introduction: The herbal medicinal product kava‐kava, used for treating anxiety disorders, was assessed positively by the Cochrane Review. However, it was withdrawn from the market in Switzerland and Germany due to cases of liver failure and ‘unproven’ efficacy. 
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Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials.
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Saffron, turmeric, St. John's wort, ginkgo, kava, and golden root are the most relevant plants that have provided important evidence for the treatment of depression in clinical trials. Expand
The Ambit of Phytotherapy in Psychotic Care
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Interestingly, the review revealed that, plant-based medicines are rich in phytonutrients of antipsychotic importance and may be effective as stand-alone treatments or supplementary to conventional interventions. Expand
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References

SHOWING 1-10 OF 12 REFERENCES
Kava treatment in patients with anxiety
In several clinical trials, mainly conducted with a dose of 300 mg kava extract per day, kava has been employed successfully for the treatment of anxiety disorders.
Kava extracts: safety and risks including rare hepatotoxicity.
TLDR
A critical analysis of the suspected cases in Germany reveals that only in 1 single patient a very probable causal relationship could be established between kava treatment and the development of toxic liver disease due to a positive result of an unscheduled reexposure test, whereas in another patient there might be a possible association. Expand
Kava kava in the treatment of generalized anxiety disorder, simple phobia and specific social phobia
TLDR
A 37‐year‐old female outpatient with generalized anxiety disorder, a simple phobia and a specific social phobia was treated with phytotherapy (Kava kava), and by 6 months an almost total remission of symptoms was observed. Expand
Kava-kava extract WS 1490 versus placebo in anxiety disorders--a randomized placebo-controlled 25-week outpatient trial.
TLDR
Results support WS 1490 as a treatment alternative to tricyclic antidepressants and benzodiazepines in anxiety disorders, with proven long-term efficacy and none of the tolerance problems associated with tricyClics and Benzodiazepine. Expand
[Effect of a special kava extract in patients with anxiety-, tension-, and excitation states of non-psychotic genesis. Double blind study with placebos over 4 weeks].
TLDR
The results of the secondary target variables were in agreement with the HAMA-score and demonstrate the efficacy of WS 1490 in patients with anxiety disorders. Expand
Kava and Valerian in the treatment of stress‐induced insomnia
TLDR
These compounds may be useful in the treatment of stress and insomnia but further studies are required to determine their relative roles for such indications. Expand
Clinical efficacy of kava extract WS 1490 in sleep disturbances associated with anxiety disorders. Results of a multicenter, randomized, placebo-controlled, double-blind clinical trial.
  • S. Lehrl
  • Psychology, Medicine
  • Journal of affective disorders
  • 2004
TLDR
It is concluded that sleep disturbances associated with non-psychotic anxiety disorders can be effectively and safely treated with kava extract WS 1490. Expand
Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social–separation–stress procedure
TLDR
It is suggested that dihydrokavain may be necessary and sufficient in mediating the anxiolytic properties of P. methysticum extract. Expand
Kava--the unfolding story: report on a work-in-progress.
TLDR
This report argues that many of the adverse events cited by the BfArM should not be attributed to kava, and proposes a number of simple measures that will ensure that safe kava preparations may continue to be available in the United Kingdom. Expand
Effect of Kava and Valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions
TLDR
The results suggest that kava and valerian may be beneficial to health by reducing physiological reactivity during stressful situations. Expand
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