Meta‐analysis of the association between the catecholamine‐O‐methyl‐transferase gene and obsessive‐compulsive disorder

@article{Azzam2003MetaanalysisOT,
  title={Meta‐analysis of the association between the catecholamine‐O‐methyl‐transferase gene and obsessive‐compulsive disorder},
  author={A. Azzam and C. Mathews},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2003},
  volume={123B}
}
  • A. Azzam, C. Mathews
  • Published 2003
  • Medicine
  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Obsessive‐compulsive disorder (OCD) is a chronic, severely debilitating mental illness that affects approximately 1–2% of the population. Data from twin and family studies have shown that genetic factors contribute to the expression of the disease. The dopaminergic system has been implicated in the pathogenesis of OCD, and catecholamine‐O‐methyl‐transferase (COMT) is a key modulator of dopaminergic and noradrenergic neurotransmission. The gene for COMT has a common polymorphism that has been… Expand
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