Meta‐analysis of randomized trials comparing combined compression and anticoagulation with either modality alone for prevention of venous thromboembolism after surgery

@article{Zarba2014MetaanalysisOR,
  title={Meta‐analysis of randomized trials comparing combined compression and anticoagulation with either modality alone for prevention of venous thromboembolism after surgery},
  author={Piotr Zaręba and C M J Wu and John Agzarian and Diana P. Rodriguez and Clive Kearon},
  journal={British Journal of Surgery},
  year={2014},
  volume={101}
}
Although venous thromboembolism (VTE) is an important cause of postoperative morbidity and mortality, there is still no consensus on the optimal strategy for VTE prevention after major surgery. The objective of this review was to determine the benefits and risks of thromboprophylaxis with both compression and anticoagulation, compared with either modality alone. 

Intermittent pneumatic compression versus additional prophylaxis with enoxaparin for prevention of venous thromboembolism after laparoscopic surgery for gastric and colorectal malignancies: multicentre randomized clinical trial

This study compared the addition of enoxaparin following intermittent pneumatic compression with IPC alone in patients undergoing laparoscopic surgery for gastrointestinal malignancy.

Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism.

This review assessed the efficacy of combined intermittent pneumatic leg compression (IPC) and pharmacological prophylaxis compared to single modalities in preventing venous thromboembolism (VTE) and the risk of bias was mostly unclear or high.

Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism.

The rate of PE in the studies comparing IPC alone with combined IPC and pharmacological prophylaxis was low, underpowering the analyses and the overall risk of bias was mostly unclear or high due to selection and performance bias.

Mechanical prophylaxis for prevention of venous thromboembolism

This work recommends against the use of GCS alone without pharmacological thromboprophylaxis for prevention of VTE in patients at intermediate and high risk and suggests combined mechanical and pharmacological prophylaxis in selected patients at very high-risk of V TE.

Mechanical Prophylaxis for Post-Traumatic VTE: Stockings and Pumps

The need for mechanical VTE prophylaxis in trauma patients, the mechanisms of clot prevention associated with the available devices, and an evidence-based look at the efficacy of the mechanical methods available for VTE Prophylax are discussed.

European guidelines on perioperative venous thromboembolism prophylaxis: Mechanical prophylaxis.

This work recommends against the use of GCS alone without pharmacological thromboprophylaxis for prevention of VTE in patients at intermediate and high risk and suggests combined mechanical and pharmacological prophylaxis in selected patients at very high risk of V TE proplylaxis.

Venous thromboembolism prophylaxis may cause more harm than benefit: an evidence-based analysis of Canadian and international guidelines

A critical review of evidence reveals that most hospitalized patients have a risk of clinical VTE equal to or lower than the bleeding risk from LMWH, and guidelines recommending liberal LMWH prophylaxis in hospitalized patients are not evidence based and should be critically re-examined.

Graduated Compression Stockings as an Adjunct to Low Dose Low Molecular Weight Heparin in Venous Thromboembolism Prevention in Surgery: A Multicentre Randomised Controlled Trial.

  • J. ShalhoubJ. Norrie A. Davies
  • Medicine
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
  • 2017

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