Meta‐analysis of dorsolateral nigral hyperintensity on magnetic resonance imaging as a marker for Parkinson's disease

  title={Meta‐analysis of dorsolateral nigral hyperintensity on magnetic resonance imaging as a marker for Parkinson's disease},
  author={Philipp Mahlknecht and Florian Krismer and Werner Poewe and Klaus Seppi},
  journal={Movement Disorders},
Dorsolateral nigral hyperintensity on iron‐sensitive magnetic resonance imaging (MRI) sequences seems to be a typical finding in Parkinson's disease (PD), but most studies have involved small samples and have had heterogeneous control populations. 

Utility of Imaging of Nigrosome‐1 on 3T MRI and Its Comparison with 18F‐DOPA PET in the Diagnosis of Idiopathic Parkinson Disease and Atypical Parkinsonism

Loss of nigrosome‐1 on 3T and 7T magnetic resonance imaging (MRI) is a recently explored imaging biomarker in the diagnosis of neurodegenerative parkinsonism.

Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

The main findings of nigrosome imaging and neuromelanin sensitive MRI studies in patients with PD and other parkinsonisms are summarized.

Screening for Early‐Stage Parkinson's Disease: Swallow Tail Sign on MRI Susceptibility Map‐Weighted Images Compared With PET

Swallow tail sign (STS) on MRI is presumed to be an imaging biomarker of nigrosome‐1, which may exhibit a similar role as positron emission tomography (PET), indicating dopaminergic degeneration.

Clinical MR imaging in Parkinson’s disease: How useful is the swallow tail sign?

The so‐called swallow tail sign (STS) has been proposed as a suitable neuroimaging marker for the diagnosis of PD, and the imaging of nigrosome‐1 (N1) is possible.

MRI of nigrosome‐1: A potential triage tool for patients with suspected parkinsonism

Whether SWI can be used as a triage tool for more efficient selection of subsequent Dopamine Transporter Scan (DaTSCAN) single‐photon emission computed tomography (SPECT) for parkinsonism is assessed.

Cortical thinning pattern according to differential nigrosome involvement in patients with Parkinson’s disease

Imaging Markers of Progression in Parkinson's Disease

Neuroimaging studies, including molecular imaging and MRI are trying to provide insights into the mechanisms underlying Parkinson's disease.

Imaging of Substantia Nigra in Parkinson’s Disease: A Narrative Review

In achieving high levels of accuracy and reproducibility in the diagnosis of PD, a multimodal MRI-PD protocol may assist neuroradiologists and clinicians in the early and differential diagnosis of a wide spectrum of neurodegenerative disorders.



Dorsolateral nigral hyperintensity on 3.0T susceptibility‐weighted imaging in neurodegenerative Parkinsonism

Absence of a hyperintense, ovoid area within the dorsolateral border of the otherwise hypointense pars compacta of the substantia nigra on iron‐sensitive high‐field magnetic resonance imaging sequences seems to be a typical finding for patients with Parkinson's disease.

Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With 123I‐FP‐CIT SPECT

The concordance between the loss of nigral hyperintensity on 3 Tesla susceptibility‐weighted imaging and the nigrostriatal dopaminergic degeneration indicated by 123I‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)‐N‐(3‐fluoropropane)‐nortropane single photon emission computerized tomography is assessed.

Nigral involvement in atypical parkinsonisms: evidence from a pilot study with ultra-high field MRI

Preserved SN in CBD confirms the pathological heterogeneity of this disease and indicates that multiple system atrophy and progressive supranuclear palsy may be linked.

Loss of dorsolateral nigral hyperintensity on 3.0 tesla susceptibility‐weighted imaging in idiopathic rapid eye movement sleep behavior disorder

It is proposed that absence of DNH on high‐field SWI could identify prodromal degenerative parkinsonism in iRBD and is in contrast to findings in HCs.

The ‘Swallow Tail’ Appearance of the Healthy Nigrosome – A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T

Assessing the substantia nigra on SWI for the typical ‘swallow tail’ appearance has potential to become a new and easy applicable 3T MRI diagnostic tool for nigral degeneration in Parkinson's disease.

Prodromal Parkinson's disease as defined per MDS research criteria in the general elderly community

Recently, the International Parkinson and Movement Disorder Society has defined research criteria for prodromal Parkinson's disease (PD), but to date their predictive value has not yet been tested in

Drug-induced Parkinsonism versus Idiopathic Parkinson Disease: Utility of Nigrosome 1 with 3-T Imaging.

The imaging of nigrosome 1 with 3-T imaging can differentiate DIP from IPD with high accuracy and may help to screen patients who need dopamine transporter imaging in those suspected of having DIP.

Visualization of nigrosome 1 and its loss in PD: Pathoanatomical correlation and in vivo 7T MRI

Editors' Note: The inability to visualize nigrosome 1 on a 7T brain MRI is suggestive of Parkinson disease, as described by Blazejewska et al. Mueller et al. report that similar sensitive and

Magnetic resonance imaging as a potential biomarker for Parkinson's disease.

  • P. Tuite
  • Medicine, Biology
    Translational research : the journal of laboratory and clinical medicine
  • 2016