Meta‐analysis of dorsolateral nigral hyperintensity on magnetic resonance imaging as a marker for Parkinson's disease

@article{Mahlknecht2017MetaanalysisOD,
  title={Meta‐analysis of dorsolateral nigral hyperintensity on magnetic resonance imaging as a marker for Parkinson's disease},
  author={Philipp Mahlknecht and Florian Krismer and Werner Poewe and Klaus Seppi},
  journal={Movement Disorders},
  year={2017},
  volume={32}
}
Dorsolateral nigral hyperintensity on iron‐sensitive magnetic resonance imaging (MRI) sequences seems to be a typical finding in Parkinson's disease (PD), but most studies have involved small samples and have had heterogeneous control populations. 
Utility of Imaging of Nigrosome‐1 on 3T MRI and Its Comparison with 18F‐DOPA PET in the Diagnosis of Idiopathic Parkinson Disease and Atypical Parkinsonism
Loss of nigrosome‐1 on 3T and 7T magnetic resonance imaging (MRI) is a recently explored imaging biomarker in the diagnosis of neurodegenerative parkinsonism.
Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism
TLDR
The main findings of nigrosome imaging and neuromelanin sensitive MRI studies in patients with PD and other parkinsonisms are summarized. Expand
Screening for Early‐Stage Parkinson's Disease: Swallow Tail Sign on MRI Susceptibility Map‐Weighted Images Compared With PET
Swallow tail sign (STS) on MRI is presumed to be an imaging biomarker of nigrosome‐1, which may exhibit a similar role as positron emission tomography (PET), indicating dopaminergic degeneration.
Clinical MR imaging in Parkinson’s disease: How useful is the swallow tail sign?
TLDR
The so‐called swallow tail sign (STS) has been proposed as a suitable neuroimaging marker for the diagnosis of PD, and the imaging of nigrosome‐1 (N1) is possible. Expand
Imaging the Nigrosome 1 in the substantia nigra using susceptibility weighted imaging and quantitative susceptibility mapping: An application to Parkinson's disease
TLDR
Nigrosome 1 can be consistently visualized using true SWI with a resolution of at least 0.67 × 0.34 mm3, which can differentiate Parkinsonism from healthy controls and not all 'Parkinson's disease patients show bilateral loss of nigrosomes 1. Expand
Cortical thinning pattern according to differential nigrosome involvement in patients with Parkinson’s disease
TLDR
Patients with Parkinsons’s disease show loss of nigrosomes on MRI that is similar to cortical thinning propagation with disease progression and Nigrosome 4 loss is associated with wider cortex thinning than nigrosome 1 loss. Expand
Imaging Markers of Progression in Parkinson's Disease
TLDR
Neuroimaging studies, including molecular imaging and MRI are trying to provide insights into the mechanisms underlying Parkinson's disease. Expand
Multiparametric MR imaging of Parkinsonisms at 3 tesla: Its role in the differentiation of idiopathic Parkinson's disease versus atypical Parkinsonian disorders.
TLDR
The combined score of midbrain atrophy and putaminal hypointensity represents a valid diagnostic pointer in the differential diagnosis of APPs from IPD. Expand
Imaging of Substantia Nigra in Parkinson’s Disease: A Narrative Review
TLDR
In achieving high levels of accuracy and reproducibility in the diagnosis of PD, a multimodal MRI-PD protocol may assist neuroradiologists and clinicians in the early and differential diagnosis of a wide spectrum of neurodegenerative disorders. Expand
Microvessels may Confound the “Swallow Tail Sign” in Normal Aged Midbrains: A Postmortem 7 T SW‐MRI Study
TLDR
Assessment of hypointense microstructures of the normal substantia nigra pars compacta at ultrahigh‐field strength for interpretation of the “swallow tail sign” in Parkinson's disease. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
Dorsolateral nigral hyperintensity on 3.0T susceptibility‐weighted imaging in neurodegenerative Parkinsonism
  • E. Reiter, C. Mueller, +8 authors K. Seppi
  • Psychology, Medicine
  • Movement disorders : official journal of the Movement Disorder Society
  • 2015
TLDR
Absence of a hyperintense, ovoid area within the dorsolateral border of the otherwise hypointense pars compacta of the substantia nigra on iron‐sensitive high‐field magnetic resonance imaging sequences seems to be a typical finding for patients with Parkinson's disease. Expand
Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With 123I‐FP‐CIT SPECT
TLDR
The concordance between the loss of nigral hyperintensity on 3 Tesla susceptibility‐weighted imaging and the nigrostriatal dopaminergic degeneration indicated by 123I‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)‐N‐(3‐fluoropropane)‐nortropane single photon emission computerized tomography is assessed. Expand
Nigral involvement in atypical parkinsonisms: evidence from a pilot study with ultra-high field MRI
TLDR
Preserved SN in CBD confirms the pathological heterogeneity of this disease and indicates that multiple system atrophy and progressive supranuclear palsy may be linked. Expand
Loss of dorsolateral nigral hyperintensity on 3.0 tesla susceptibility‐weighted imaging in idiopathic rapid eye movement sleep behavior disorder
TLDR
It is proposed that absence of DNH on high‐field SWI could identify prodromal degenerative parkinsonism in iRBD and is in contrast to findings in HCs. Expand
Loss of substantia nigra hyperintensity on 7 Tesla MRI of Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
TLDR
7T MRI represents an excellent tool for evaluating nigral hyperintensity in PD, MSA, and PSP, with tolerable side effects and limited motion artifacts, and imaging of parkinsonism may benefit from using 7T MRI. Expand
The ‘Swallow Tail’ Appearance of the Healthy Nigrosome – A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T
TLDR
Assessing the substantia nigra on SWI for the typical ‘swallow tail’ appearance has potential to become a new and easy applicable 3T MRI diagnostic tool for nigral degeneration in Parkinson's disease. Expand
Prodromal Parkinson's disease as defined per MDS research criteria in the general elderly community
Recently, the International Parkinson and Movement Disorder Society has defined research criteria for prodromal Parkinson's disease (PD), but to date their predictive value has not yet been tested inExpand
Drug-induced Parkinsonism versus Idiopathic Parkinson Disease: Utility of Nigrosome 1 with 3-T Imaging.
TLDR
The imaging of nigrosome 1 with 3-T imaging can differentiate DIP from IPD with high accuracy and may help to screen patients who need dopamine transporter imaging in those suspected of having DIP. Expand
Visualization of nigrosome 1 and its loss in PD: Pathoanatomical correlation and in vivo 7T MRI
Editors' Note: The inability to visualize nigrosome 1 on a 7T brain MRI is suggestive of Parkinson disease, as described by Blazejewska et al. Mueller et al. report that similar sensitive andExpand
Magnetic resonance imaging as a potential biomarker for Parkinson's disease.
  • P. Tuite
  • Medicine
  • Translational research : the journal of laboratory and clinical medicine
  • 2016
Although a magnetic resonance imaging (MRI) biomarker for Parkinson's disease (PD) remains an unfulfilled objective, there have been numerous developments in MRI methodology and some of these haveExpand
...
1
2
3
4
...