Meta‐analysis of association between obsessive‐compulsive disorder and the 3′ region of neuronal glutamate transporter gene SLC1A1

@article{Stewart2013MetaanalysisOA,
  title={Meta‐analysis of association between obsessive‐compulsive disorder and the 3′ region of neuronal glutamate transporter gene SLC1A1},
  author={S. Evelyn Stewart and C Mayerfeld and Paul D. Arnold and Jacquelyn Crane and Colm O'Dushlaine and Jesen A. Fagerness and D. Yu and J M Scharf and Eh Chan and F Kassam and Pablo R Moya and Jens R. Wendland and Richard Delorme and Margaret Anne Richter and James L. Kennedy and Jeremy Veenstra-VanderWeele and J. F. Samuels and Benjamin D. Greenberg and James T. McCracken and James A. Knowles and Abby J Fyer and Scott L. Rauch and Mark A. Riddle and Marco A Grados and O. Joseph Bienvenu and Bernadette A. Cullen and Ying Wang and Yin Yao Shugart and John Piacentini and Steven A. Rasmussen and Gerald Nestadt and Dennis L. Murphy and Michael A. Jenike and Edwin H. Cook and David L. Pauls and Gregory L. Hanna and Carol A. Mathews},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2013},
  volume={162}
}
The neuronal glutamate transporter gene SLC1A1 is a candidate gene for obsessive‐compulsive disorder (OCD) based on linkage studies and convergent evidence implicating glutamate in OCD etiology. The 3′ end of SLC1A1 is the only genomic region with consistently demonstrated OCD association, especially when analyzing male‐only probands. However, specific allele associations have not been consistently replicated, and recent OCD genome‐wide association and meta‐analysis studies have not… 
Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean population
TLDR
The results suggest that six common SNPs of SLC1A1 may not contribute to the development of OCD, but may contribute to certain aspect of trait empathy such as personal distress, however, insufficient sample size and limited number of SNPs may have reduced the likelihood of detecting significant associations.
Disorder‐specific genetic factors in obsessive‐compulsive disorder: A comprehensive meta‐analysis
  • Steven Taylor
  • Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2016
TLDR
It is confirmed that OCD is associated with polymorphisms of 5‐HTTLPR, HTR2A, and, in males only, COMT, which were not associated with almost all other forms of psychopathology, including unipolar mood disorders, bipolar disorder, panic disorder, schizophrenia, and alcohol dependence.
Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis
TLDR
A meta-analysis from two independent OCD consortia, investigating a total of 2688 individuals of European ancestry with OCD and 7037 genomically matched controls, concludes that the largest single OCD genome-wide study to date represents a major integrative step in elucidating the genetic causes of OCD.
Genome-Wide Association Study in Obsessive-Compulsive Disorder: Results from the OCGAS
TLDR
Assessment of comprehensively assessed OCD patients with an early age of OCD onset revealed association of IQCK and C16orf88, as well as OFCC1 and PTPRD, and follow-up analyses of genome-wide association study signals from a previously published OCD study identified significant enrichment.
A Genetic Association Study of Glutamate Transporter Genes SLC1A1 and SLC1A3 in Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder
TLDR
Considering that several trends for association are observed, studies using larger samples are required to determine whether these genes are associated with TS or ADHD, and none of the genotyped markers remained significant following corrections for multiple testing.
Molecular Genetics of Obsessive-Compulsive Disorder
Genetic association studies of obsessive-compulsive disorder (OCD) have yielded inconsistent findings because those studies have tended to have small sample sizes and low statistical power, thereby
Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen.
TLDR
Evidence of significant positive concordance is found between OCD risk variants and variants associated with greater nucleus accumbens and putamen volumes, which are consistent with current OCD neurocircuitry models.
Genome-wide Association Study of Pediatric Obsessive-Compulsive Traits: Shared Genetic Risk between Traits and Disorder
TLDR
It is indicated that OC traits in the general population share genetic risk with OCD in independent samples and the feasibility and power of using trait-based approaches in community samples in psychiatric genomics are demonstrated.
OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior
TLDR
A model of Slc1a1 loss based on an excisable STOP cassette that yields successful ablation of EAAT3 expression and function is reported, indicating that the most consistently associated OCD candidate gene impacts basal ganglia-dependent repetitive behaviors.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 105 REFERENCES
A family‐based association study of the glutamate transporter gene SLC1A1 in obsessive–compulsive disorder in 378 families
  • Y. Shugart, Y. Wang, +17 authors G. Nestadt
  • Biology, Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2009
TLDR
A family‐based association study, which examined the association between 13 single nucleotide polymorphisms within or in proximity to the SLC1A1 gene, indicated a strong association signal with the SNP RS301443, which was not previously reported by the other research groups.
Comprehensive family‐based association study of the glutamate transporter gene SLC1A1 in obsessive‐compulsive disorder
  • J. Samuels, Y. Wang, +16 authors G. Nestadt
  • Biology, Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2011
TLDR
None of the surrounding markers were in linkage disequilibrium with rs301443, nor were any associated with OCD, and these findings provide further support for the involvement of SLC1A1 in the pathogenesis of OCD.
Association of the SLC1A1 glutamate transporter gene and obsessive‐compulsive disorder
  • S. Stewart, J. Fagerness, +9 authors D. Pauls
  • Biology, Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2007
TLDR
A significant association between the SLC1A1 glutamate transporter gene and OCD is identified in a haplotype overlapping with that recently reported.
Association Between Polymorphisms in GRIK2 Gene and Obsessive‐Compulsive Disorder: A Family‐Based Study
TLDR
This study supports previously reported findings of association between proximal GRIK2 SNPs and OCD in a comprehensive evaluation of the gene.
Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder.
TLDR
Preliminary evidence that sequence variation in SLC1A1 is associated with susceptibility to OCD, particularly in males is provided, and support for the role of altered glutamatergic neurotransmission in the pathogenesis of OCD is provided.
Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder.
TLDR
The 3' region of SLC1A1 may contain a susceptibility allele for early-onset OCD, with differential effects in males and females, and provides further support for the involvement of a glutamatergic dysfunction in the pathogenesis of early-ONSet OCD.
Evidence for potential relationship between SLC1A1 and a putative genetic linkage region on chromosome 14q to obsessive‐compulsive disorder with compulsive hoarding
  • K. Liang, Y. Wang, +17 authors G. Nestadt
  • Biology, Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
Using the analytic program GENEFINDER, conditioning linkage on chromosome 14q to a marker adjacent to SLC1A1, reduced the size of the linkage region on chromosomes 14q and provided evidence for interaction between the regions on chromosomes 9p and 14q.
A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder.
TLDR
The authors' case-control data corroborate previous smaller family-based studies that indicated that SLC1A1 is a susceptibility locus for OCD and provide a potentially useful complementary approach to strengthen future candidate gene studies in neuropsychiatric and other disorders.
Molecular genetics of obsessive–compulsive disorder: a comprehensive meta-analysis of genetic association studies
  • S. Taylor
  • Psychology, Medicine
    Molecular Psychiatry
  • 2013
TLDR
It is demonstrated that OCD is associated with multiple genes, with most having a modest association with OCD, which suggests a polygenic model of OCD, consistent with twin studies, in which multiple genes make small, incremental contributions to the risk of developing the disorder.
A screen of SLC1A1 for OCD‐related alleles
  • Y. Wang, A. Adamczyk, +19 authors G. Nestadt
  • Biology, Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2010
TLDR
This study conducted capillary electrophoresis single‐strand conformation polymorphism (CE‐SSCP) screen for all 12 identified exons, including all coding regions and ∼50 bp of flanking introns of the human SLC1A1 in 378 OCD‐affected individuals and 281 ethnically matched controls to determine if there are differences in the frequencies of relatively common alleles, or rare functional alleles.
...
1
2
3
4
5
...