Meta‐analysis of association between obsessive‐compulsive disorder and the 3′ region of neuronal glutamate transporter gene SLC1A1

@article{Stewart2013MetaanalysisOA,
  title={Meta‐analysis of association between obsessive‐compulsive disorder and the 3′ region of neuronal glutamate transporter gene SLC1A1},
  author={S. Stewart and C. Mayerfeld and P. Arnold and J. R. Crane and C. O’Dushlaine and J. Fagerness and D. Yu and J. Scharf and E. Chan and F. Kassam and P. Moya and J. Wendland and R. Delorme and M. Richter and J. L. Kennedy and J. Veenstra-Vanderweele and J. Samuels and B. Greenberg and J. McCracken and J. Knowles and A. Fyer and S. Rauch and M. Riddle and M. Grados and O. Bienvenu and B. Cullen and Y. Wang and Y. Shugart and J. Piacentini and S. Rasmussen and G. Nestadt and D. Murphy and M. Jenike and E. Cook and D. Pauls and G. Hanna and C. Mathews},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2013},
  volume={162}
}
  • S. Stewart, C. Mayerfeld, +34 authors C. Mathews
  • Published 2013
  • Medicine
  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
  • The neuronal glutamate transporter gene SLC1A1 is a candidate gene for obsessive‐compulsive disorder (OCD) based on linkage studies and convergent evidence implicating glutamate in OCD etiology. The 3′ end of SLC1A1 is the only genomic region with consistently demonstrated OCD association, especially when analyzing male‐only probands. However, specific allele associations have not been consistently replicated, and recent OCD genome‐wide association and meta‐analysis studies have not… CONTINUE READING
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