Meta‐analysis of B type natriuretic peptide and N‐terminal pro B natriuretic peptide in the diagnosis of clinical heart failure and population screening for left ventricular systolic dysfunction

@article{Ewald2008MetaanalysisOB,
  title={Meta‐analysis of B type natriuretic peptide and N‐terminal pro B natriuretic peptide in the diagnosis of clinical heart failure and population screening for left ventricular systolic dysfunction},
  author={Ben D. Ewald and D Ewald and Ammarin Thakkinstian and John Attia},
  journal={Internal Medicine Journal},
  year={2008},
  volume={38}
}
Background:  We set out to review the validity of tests for B type natriuretic peptide (BNP) and N‐terminal pro BNP (NTproBNP) in the diagnosis of clinical heart failure (HF) in primary care and hospital settings and to examine the effect of age. We also examined the accuracy of the test in population screening for left ventricular systolic dysfunction. 
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TLDR
A report from the CHS (Cardiovascular Health Study) on an assessment of N-terminal prophylaxis in the elderly is reported. Expand
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TLDR
The addition of BNP and NT-proBNP to usual clinical decision making enhances detection of high-risk patients who need aggressive follow-up and adjustment of treatment. Expand
N-terminal pro-b-type natriuretic peptide and left atrial function in patients with congestive heart failure and severely reduced ejection fraction.
TLDR
In CHF patients with severely impaired systolic function, NT-pro-BNP levels reflect LA and LV dysfunction, and should prompt studies to investigate the relationship between changes of LA function and NT- pro-BNp levels and their clinical value as prognostic and therapeutic targets in CHF. Expand
Hemoglobin Concentration Influences N‐Terminal Pro B‐Type Natriuretic Peptide Levels in Hospitalized Older Adults with and without Heart Failure
TLDR
To investigate the relationship between hemoglobin and N‐terminal pro B‐type natriuretic peptide (NT‐proBNP) concentration in hospitalized older adults with or without a diagnosis of heart failure, a large number of subjects were treated for heart failure. Expand
Comprehensive Review of the Relative Clinical Utility of B-Type Natriuretic Peptide and N-Terminal Pro-B-Type Natriuretic Peptide Assays in Cardiovascular Disease
TLDR
While optimal diagnostic cutpoints for both markers varied depended on age and degree of renal dysfunction, and the clinical application; NT-proBNP had a much more widely variable optimal cutpoint than did BNP, sufficient evidence for clinical utility of both tests exists for other applications of prognosis, screening, and monitoring of heart failure. Expand
The role of b-type natriuretic peptide in heart failure management.
TLDR
There is enthusiasm for use of BNP as a marker of heart failure severity as well as a predictor of outcomes in people with heart failure and trials are ongoing. Expand
Natriuretic peptide testing in primary care patients
TLDR
Plasma concentration of B-type-related natriuretic peptides is a marker of either hemodynamic or neurohormonal stress on the heart and has been validated within the diagnostic and prognostic domain in patients with suspected or ascertained heart failure, mostly in the in-hospital setting. Expand
Natriuretic peptide measurement in heart failure
This paper is an up-to-date account of research and current clinical practice guideline recommendations. Chris Higgins summarizes the recommendations of 2 new guidance documents on the use ofExpand
Clinical relevance of BNP measurement in the follow-up of patients with chronic heart failure.
TLDR
In this chapter, authors have studied the clinical impact of B-type natriuretic peptide assay in the follow-up of patients with heart failure, and, in particular, the possible role of the measurement of its circulating levels in guiding the treatment. Expand
Natriuretic peptides as indicators of cardiac remodeling in hypertensive patients
TLDR
Nt-BNP and BNP are useful to discriminate between patients with regard to cardiac remodeling and might be considered a screening tool in order select patients eligible for further examination with UCG examination. Expand
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