Meta‐analysis examining the epidemiology of clozapine‐associated neutropenia

@article{Myles2018MetaanalysisET,
  title={Meta‐analysis examining the epidemiology of clozapine‐associated neutropenia},
  author={Nicholas Myles and Hannah Myles and Shelley Xia and Matthew Large and Stephen R. Kisely and Cherrie A Galletly and Robert J Bird and Dan J. Siskind},
  journal={Acta Psychiatrica Scandinavica},
  year={2018},
  volume={138}
}
Clozapine is associated with life‐threatening neutropenia. There are no previous meta‐analyses of the epidemiology of clozapine‐associated neutropenia. 
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100 Citations
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100 Citations

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References

SHOWING 1-10 OF 23 REFERENCES

Neutropenia and Agranulocytosis in Patients Receiving Clozapine in the UK and Ireland

The use of a patient monitoring service kept the haematological risks associated with using clozapine within acceptable limits, particularly in view of the benefits of this medication in treatment-resistant schizophrenia.

Active monitoring of 12760 clozapine recipients in the UK and Ireland

The case register yielded valuable information for guiding research into the causes of the haematological reactions in subjects receiving clozapine, and the risk for agranulocytosis in Asian subjects was 2.4 times that in Caucasians.

International trends in clozapine use: a study in 17 countries

This study aimed to assess clozapine use trends on an international scale, using standardised criteria for data analysis.

Agranulocytosis during treatment with clozapine

Within six months of the introduction of the new antipsychotic drug clozapine in Finland, 17 cases of neutropenia or agranulocytosis were recorded amongst about 3000 patients treated, with a high incidence of complications.

Reducing clozapine-related morbidity and mortality: 5 years of experience with the Clozaril National Registry.

The estimated impact of the CNR on clozapine-related morbidity and mortality over the first 5 years of commercial experience in the United States is reviewed.

Clozapine-induced agranulocytosis. Incidence and risk factors in the United States.

The increasing risk of agranulocytosis with age and the reduced incidence after the first six months of treatment provide additional guidelines for the prescription and monitoring of clozapine treatment in the future.

Clozapine v. first- and second-generation antipsychotics in treatment-refractory schizophrenia: systematic review and meta-analysis

Clozapine is superior for treatment-refractory disorder but if there is no response by 6 months medications with lower adverse reactions should be considered.

Mortality and Self-Harm in Association With Clozapine in Treatment-Resistant Schizophrenia.

Rates of all-cause mortality and self-harm in association with clozapine treatment in individuals with treatment-resistant schizophrenia demonstrate a nearly twofold higher mortality rate and suggest a harmful effect of other antipsychotics regarding self- Harm compared with clazapine.

Idiosyncratic drug-induced agranulocytosis or acute neutropenia

Idiosyncratic drug-induced agranulocytosis or acute neutropenia is an adverse event resulting in a neutrophil count under 0.5 × 109/l and healthcare professionals should be aware of this adverse event and its management.

Population-based drug-induced agranulocytosis.

Agranulocytosis is rare but serious, and a few drugs account for two thirds of the cases, and the results provide reassurance regarding the risk associated with a number of newly marketed drugs.