Meta‐analysis: comparison of oral vs. intravenous proton pump inhibitors in patients with peptic ulcer bleeding

@article{Tsoi2013MetaanalysisCO,
  title={Meta‐analysis: comparison of oral vs. intravenous proton pump inhibitors in patients with peptic ulcer bleeding},
  author={Kevin F. W Tsoi and Hoyee W. Hirai and Joesph Jy Sung},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2013},
  volume={38}
}
The efficacy of adjuvant use of intravenous proton pump inhibitors (PPIs) after endoscopic therapy has been proved in peptic ulcer bleeding patients, but the efficacy of oral PPIs is uncertain. 

Paper Mentions

Interventional Clinical Trial
Upper gastrointestinal hemorrhage (UGIH) is common urgency condition.The estimate mortality rate about 7 percent from peptic ulcers disease(PUD). A proton pump inhibitors (PPIs… Expand
ConditionsPeptic Ulcer With Haemorrhage
InterventionDrug
Intravenous vs. Oral Proton-Pump Inhibitors for Bleeding Peptic Ulcers
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TLDR
This study determined the most efficient PPI regimen and optimal timing of endoscopy in acute peptic ulcer bleeding and recommended the most effective schedule of proton pump inhibitor administration. Expand
Meta‐analysis: proton‐pump inhibition in high‐risk patients with acute peptic ulcer bleeding
TLDR
Current data suggest that profound acid suppression may improve outcomes of patients in peptic ulcer bleeding, and this work is likely to be a first step in this direction. Expand
Comparison of p.o. or i.v. proton pump inhibitors on 72‐h intragastric pH in bleeding peptic ulcer
TLDR
Evaluating the effect of various proton pump inhibitors given through different routes on intragastric pH over 72 h after endoscopic hemostasis in bleeding peptic ulcer found them to reduce the rate of recurrent bleeding by maintaining intragASTric pH at neutral level. Expand
Oral versus intravenous proton pump inhibitors in preventing re-bleeding for patients with peptic ulcer bleeding after successful endoscopic therapy
TLDR
There is no evidence of a difference in clinical outcomes between oral and intravenous PPI treatment, however, the study was not powered to prove equivalence or non-inferiority. Expand
Comparison of Oral and Intravenous Proton Pump Inhibitor on Patients with High Risk Bleeding Peptic Ulcers: A Prospective, Randomized, Controlled Clinical Trial
TLDR
Oral omeprazole and IV pantoprazole had equal effects on prevention of rebleeding after endoscopic therapy in patients with high risk bleeding peptic ulcers. Expand
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TLDR
PPI treatment in PU bleeding reduces rebleeding and surgical intervention rates in studies comparing treatment with placebo or H(2)RA, but there is no evidence of an effect on mortality. Expand
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Pantoprazole is a proton pump inhibitor characterized by a low potential to interact with the cytochrome P450 system, and linear pharmacokinetics. The recommended oral dose for treatment ofExpand
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TLDR
PI treatment in PU bleeding reduces rebleeding and surgery compared with placebo or H(2)RA, but there is no evidence of an overall effect on all-cause mortality. Expand
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TLDR
Oral rabeprazoles and i.v. regular-dose omeprazole are equally effective in preventing rebleeding in patients with high-risk bleeding peptic ulcers after successful endoscopic injection with epinephrine. Expand
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TLDR
High-dose intravenous esomeprazole given after successful endoscopic therapy to patients with high-risk peptic ulcer bleeding reduced recurrent bleeding at 72 hours and had sustained clinical benefits for up to 30 days. Expand
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