Meta‐Analysis of Natural Therapies for Hyperlipidemia: Plant Sterols and Stanols versus Policosanol

  title={Meta‐Analysis of Natural Therapies for Hyperlipidemia: Plant Sterols and Stanols versus Policosanol},
  author={Judy T. Chen and Robert A. Wesley and Robert D. Shamburek and Frank Pucino and Gyorgy Csako},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
Study Objective. To compare the efficacy and safety of plant sterols and stanols as well as policosanol in the treatment of coronary heart disease, as measured by a reduction in low‐density lipoprotein cholesterol (LDL) levels. 
Lipid lowering effect of policosanol and omega-3 fatty acids combined therapy in hypercholesterolemic patients
Resumen es: Aunque el colesterol de las lipoproteinas de baja densidad (LDL-C) continua siendo el principal objetivo en el manejo de la dislipidemia, la prevencion d...
Efficacy of Plant Sterol-Enriched Food for Primary Prevention and Treatment of Hypercholesterolemia: A Systematic Literature Review
It can be concluded that PSs can be used as an important primary prevention measure for hypercholesterolemia and as tertiary prevention for cardiovascular events in patients who already have mild to moderate LDL-c.
Phytosterols for dyslipidemia.
  • J. M. Malinowski, M. Gehret
  • Medicine, Biology
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2010
Overall, phytosterols are useful for reducing LDL cholesterol in patients who cannot reach their treatment goal by diet alone or who are taking maximum tolerated doses of statins.
Enhancement of HDL by Policosanol
  • Kyung-Hyun Cho
  • Medicine
    High-Density Lipoproteins as Biomarkers and Therapeutic Tools
  • 2019
It is well established that a higher level of serum HDL-cholesterol is associated with lower incidence of coronary artery disease and increased longevity and it has been reported that consumption of PCO can significantly reduce serum total cholesterol and LDL-ch cholesterol levels as well as raise serum cholesterol levels.
Evaluation of cholesterol-lowering and antioxidant properties of sugar cane policosanols in hamsters and humans
The aim of this thesis project was first to compare the composition and cholesterol-lowering effects of different SCP preparations in hamsters, and second to test the cholesterol- Lowering efficacy, mechanism of action, and antioxidant capacity of original SCPs in humans.
Biological activities of phytosterols with particular attention to their effects on lipid metabolism
The objective of this review is to discuss the results of available studies concerning metabolic effects of phytosterols with a closer look at their impact on lipid metabolism in humans.
The comparative efficacy of plant sterols and stanols on serum lipids: a systematic review and meta-analysis.
Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia: a randomized controlled trial.
In patients with hypercholesterolemia or combined hyperlipidemia, the sugar cane-derived policosanol in usual and high doses does not demonstrate a reduction in lipid levels beyond placebo.


Antiplatelet effects of policosanol (20 and 40 mg/day) in healthy volunteers and dyslipidaemic patients
The effects of a higher dose of policosanol, a cholesterol‐lowering drug, with the effects of 20 mg/day policeosanol on platelet aggregation in healthy volunteers and type II hypercholesterolaemic patients are compared.
Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent.
Policosanol seems to be a very promising phytochemical alternative to classic lipid-lowering agents such as the statins and deserves further evaluation.
Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels.
Present evidence is sufficient to promote use of sterols and stanols for lowering LDL cholesterol levels in persons at increased risk for coronary heart disease.
Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia.
  • M. Denke
  • Medicine
    The American journal of clinical nutrition
  • 1995
Although previous reports have suggested that low-dose sitostanol therapy is an effective means of reducing LDL-cholesterol concentrations, its effectiveness may be attenuated when the diet is low in cholesterol.
Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men.
Addition of blended phytosterols to a prudent North American diet improved plasma LDL-cholesterol concentrations by mechanisms that did not result in significant changes in endogenous cholesterol synthesis in hypercholesterolemic men.