Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type

@article{Ribass2003Met66IT,
  title={Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type},
  author={Marta Ribas{\'e}s and M{\'o}nica Gratac{\'o}s and Ll Armengol and Rafael de Cid and Anna Bad{\'i}a and Laura Aguilera Jim{\'e}nez and Raquel Solano and Julio Vallejo and Fernando L{\'o}pez Fern{\'a}ndez and Xavier Estivill},
  journal={Molecular Psychiatry},
  year={2003},
  volume={8},
  pages={745-751}
}
Several lines of evidence support a role for brain-derived neurotrophic factor (BDNF) alterations in the etiology of eating disorders (EDs). BDNF heterozygous knockout mice show alterations in eating behavior, increased body weight and adipocyte hypertrophy. BDNF also regulates the synaptic efficiency through the modulation of key neurotransmitter systems previously known to be involved in ED. These findings, together with the fact that this neurotrophin is expressed in the hypothalamus nuclei… CONTINUE READING
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