Met tyrosine kinase inhibitor, PF-2341066, suppresses growth and invasion of nasopharyngeal carcinoma

Abstract

PURPOSE We explored the effect of hepatocyte growth factor (HGF)/Met signaling pathway on nasopharyngeal carcinoma (NPC) cells in vitro and in vivo, and investigated the ability of Met tyrosine kinase inhibitor (TKI) to block HGF-induced biological signaling. EXPERIMENTAL DESIGN Met TKI inhibitor PF-2341066 alone, or in combination with cisplatin, was… (More)
DOI: 10.2147/DDDT.S85837

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