Met signaling in cardiomyocytes is required for normal cardiac function in adult mice.

@article{Arechederra2013MetSI,
  title={Met signaling in cardiomyocytes is required for normal cardiac function in adult mice.},
  author={Mar{\'i}a Arechederra and Rita Carmona and Maria Angeles Gonzalez-Nu{\~n}ez and {\'A}lvaro Guti{\'e}rrez-Uzquiza and Paloma Bragado and ignacio Cruz-Gonzalez and Elena Cano and Carmen Guerrero and Ar{\'a}nzazu S{\'a}nchez and Jos{\'e} Miguel L{\'o}pez-Novoa and Michael H. Schneider and Flavio Maina and Ram{\'o}n Mu{\~n}oz-Ch{\'a}puli and Almudena Porras},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1832 12},
  pages={2204-15}
}
Hepatocyte growth factor (HGF) and its receptor, Met, are key determinants of distinct developmental processes. Although HGF exerts cardio-protective effects in a number of cardiac pathologies, it remains unknown whether HGF/Met signaling is essential for myocardial development and/or physiological function in adulthood. We therefore investigated the requirement of HGF/Met signaling in cardiomyocyte for embryonic and postnatal heart development and function by conditional inactivation of the… CONTINUE READING
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