Met receptor tyrosine kinase signals through a cortactin–Gab1 scaffold complex, to mediate invadopodia

@inproceedings{Rajadurai2012MetRT,
  title={Met receptor tyrosine kinase signals through a cortactin–Gab1 scaffold complex, to mediate invadopodia},
  author={Charles V Rajadurai and Serhiy Havrylov and Kossay Zaoui and Richard R. Vaillancourt and Matthew Stuible and Monica A Naujokas and Dongmei Zuo and Michel L Tremblay and Morag Park},
  booktitle={Journal of cell science},
  year={2012}
}
Invasive carcinoma cells form actin-rich matrix-degrading protrusions called invadopodia. These structures resemble podosomes produced by some normal cells and play a crucial role in extracellular matrix remodeling. In cancer, formation of invadopodia is strongly associated with invasive potential. Although deregulated signals from the receptor tyrosine kinase Met (also known as hepatocyte growth factor are linked to cancer metastasis and poor prognosis, its role in invadopodia formation is not… CONTINUE READING