Met interacts with EGFR and Ron in canine osteosarcoma.

@article{McCleese2013MetIW,
  title={Met interacts with EGFR and Ron in canine osteosarcoma.},
  author={Jennifer K McCleese and Misty D Bear and Samuel K. Kulp and Christina N Mazcko and C. K. Raghul Khanna and Cheryl A London},
  journal={Veterinary and comparative oncology},
  year={2013},
  volume={11 2},
  pages={
          124-39
        }
}
The receptor tyrosine kinase (RTK) Met is known to be over-expressed in canine osteosarcoma (OSA). In human cancers, the RTKs Met, epidermal growth factor receptor (EGFR) and Ron are frequently co-expressed and engage in heterodimerization, altering signal transduction and promoting resistance to targeted therapeutics. We found that EGFR and Ron are expressed in canine OSA cell lines and primary tissues, EGFR and Ron are frequently phosphorylated in OSA tumour samples, and Met is co-associated… CONTINUE READING
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