Met-enkephalin is preferentially transported into the peripheral processes of primary afferent fibres in both control and HSV1-driven proenkephalin A overexpressing rats.

@article{bras2001MetenkephalinIP,
  title={Met-enkephalin is preferentially transported into the peripheral processes of primary afferent fibres in both control and HSV1-driven proenkephalin A overexpressing rats.},
  author={J Antunes bras and C Becker and Sylvie Bourgoin and M Lombard and François Cesselin and Michel Hamon and Michel Pohl},
  journal={Neuroscience},
  year={2001},
  volume={103 4},
  pages={1073-83}
}
The demonstration of preproenkephalin A gene expression in rat dorsal root ganglia has raised the question of the physiological role of met-enkephalin-containing primary afferent fibres. Recently, we showed that systemic infection with a recombinant Herpes simplex virus encoding preproenkephalin A (HSVLatEnk1) yielded a marked increase in the density of met-enkephalin-like material synthesising neurons in rat dorsal root ganglia. This study further investigated the synthesis, transport and… CONTINUE READING
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