Met-HGF/SF: tumorigenesis, invasion and metastasis.

  title={Met-HGF/SF: tumorigenesis, invasion and metastasis.},
  author={George F. Vande Woude and Michael Jeffers and J S Cortner and Gregory W Alvord and Ilan Tsarfaty and J Resau},
  journal={Ciba Foundation symposium},
  pages={119-30; discussion 130-2, 148-54}
Hepatocyte growth factor/scatter factor (HGF/SF) is synthesized by mesenchymal cells and is a paracrine effector of cells, predominantly epithelial, that express the Met tyrosine kinase receptor. We have demonstrated that autocrine Met-HGF/SF expression in mouse fibroblasts results in transformation and tumorigenesis. HGF/SF-treated cells expressing Met can respond in a variety of ways: mitogenically, by scattering (motility), and by forming branching tubules in gel matrices (branching… CONTINUE READING