Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?

@inproceedings{Minde2011MessingUD,
  title={Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?},
  author={David P. Minde and Zeinab Anvarian and Stefan G D R{\"u}diger and Madelon M Maurice},
  booktitle={Molecular Cancer},
  year={2011}
}
SummaryMutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors. Central to the tumorigenic events in APC mutant cells is the uncontrolled stabilization and transcriptional activation of the protein β-catenin. Many questions remain as to how APC controls β-catenin degradation. Remarkably, the large C-terminal region of APC, which spans over 2000 amino acids and includes critical regions in downregulating β-catenin, is… CONTINUE READING

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