Messenger ribonucleic acid expression of 16 matrix metalloproteinases in bone-implant interface tissues of loose artificial hip joints.

@article{Takei2000MessengerRA,
  title={Messenger ribonucleic acid expression of 16 matrix metalloproteinases in bone-implant interface tissues of loose artificial hip joints.},
  author={Izumi Takei and Michiaki Takagi and Seppo Santavirta and Hiroaki Ida and Masaru Ishii and Toshihiko Ogino and Mari Ainola and Yrj{\"o} T. Konttinen},
  journal={Journal of biomedical materials research},
  year={2000},
  volume={52 4},
  pages={613-20}
}
Matrix metalloproteinases (MMPs) have been reported to be the major factors responsible for aseptic loosening of artificial hip joints. So far, messenger ribonucleic acid (mRNA) expression patterns of seven MMPs have been reported, but that of many other MMPs which have been newly discovered or recently considered to be responsible for prosthetic loosening is still unknown. In this study, mRNA expression pattern of 16 different types of MMPs were analyzed to evaluate which MMPs were locally… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
Based on local expression pattern of MMPs at the mRNA level , aseptic loose artificial hip joint was characterized by elevated expression of MMP-1 , MMP-9 , MMP-10 , MMP-12 , and MMP-13 ; moderate expression of MMP-2 , MMP-7 , MMP-8 , MMP-11 , membrane type ( MT)1-MMP ( MMP-14 ) , MT2-MMP ( MMP-15 ) , MT3-MMP ( MMP-16 ) , MT4-MMP ( MMP-17 ) , and MMP-19 ; lower expression of MMP-3 ; and little significance of MMP-20 .
Based on local expression pattern of MMPs at the mRNA level , aseptic loose artificial hip joint was characterized by elevated expression of MMP-1 , MMP-9 , MMP-10 , MMP-12 , and MMP-13 ; moderate expression of MMP-2 , MMP-7 , MMP-8 , MMP-11 , membrane type ( MT)1-MMP ( MMP-14 ) , MT2-MMP ( MMP-15 ) , MT3-MMP ( MMP-16 ) , MT4-MMP ( MMP-17 ) , and MMP-19 ; lower expression of MMP-3 ; and little significance of MMP-20 .
Based on local expression pattern of MMPs at the mRNA level , aseptic loose artificial hip joint was characterized by elevated expression of MMP-1 , MMP-9 , MMP-10 , MMP-12 , and MMP-13 ; moderate expression of MMP-2 , MMP-7 , MMP-8 , MMP-11 , membrane type ( MT)1-MMP ( MMP-14 ) , MT2-MMP ( MMP-15 ) , MT3-MMP ( MMP-16 ) , MT4-MMP ( MMP-17 ) , and MMP-19 ; lower expression of MMP-3 ; and little significance of MMP-20 .
Matrix metalloproteinases ( MMPs ) have been reported to be the major factors responsible for aseptic loosening of artificial hip joints .
Based on local expression pattern of MMPs at the mRNA level , aseptic loose artificial hip joint was characterized by elevated expression of MMP-1 , MMP-9 , MMP-10 , MMP-12 , and MMP-13 ; moderate expression of MMP-2 , MMP-7 , MMP-8 , MMP-11 , membrane type ( MT)1-MMP ( MMP-14 ) , MT2-MMP ( MMP-15 ) , MT3-MMP ( MMP-16 ) , MT4-MMP ( MMP-17 ) , and MMP-19 ; lower expression of MMP-3 ; and little significance of MMP-20 .
Based on local expression pattern of MMPs at the mRNA level , aseptic loose artificial hip joint was characterized by elevated expression of MMP-1 , MMP-9 , MMP-10 , MMP-12 , and MMP-13 ; moderate expression of MMP-2 , MMP-7 , MMP-8 , MMP-11 , membrane type ( MT)1-MMP ( MMP-14 ) , MT2-MMP ( MMP-15 ) , MT3-MMP ( MMP-16 ) , MT4-MMP ( MMP-17 ) , and MMP-19 ; lower expression of MMP-3 ; and little significance of MMP-20 .
Based on local expression pattern of MMPs at the mRNA level , aseptic loose artificial hip joint was characterized by elevated expression of MMP-1 , MMP-9 , MMP-10 , MMP-12 , and MMP-13 ; moderate expression of MMP-2 , MMP-7 , MMP-8 , MMP-11 , membrane type ( MT)1-MMP ( MMP-14 ) , MT2-MMP ( MMP-15 ) , MT3-MMP ( MMP-16 ) , MT4-MMP ( MMP-17 ) , and MMP-19 ; lower expression of MMP-3 ; and little significance of MMP-20 .
All Topics