Messenger molecules of the phospholipase signaling system have dual effects on vascular smooth muscle contraction.

@article{Vidulescu2000MessengerMO,
  title={Messenger molecules of the phospholipase signaling system have dual effects on vascular smooth muscle contraction.},
  author={Cristina Vidulescu and Jean Mironneau and Chantal Mironneau and Lawrence M Popescu},
  journal={Journal of cellular and molecular medicine},
  year={2000},
  volume={4 3},
  pages={196-206}
}
Background and methods. In order to investigate the role of phospholipases and their immediately derived messengers in agonist-induced contraction of portal vein smooth muscle, we used the addition in the organ bath of exogenous molecules such as: phospholipases C, A(2), and D, diacylglycerol, arachidonic acid, phosphatidic acid, choline. We also used substances modulating activity of downstream molecules like protein kinase C, phosphatidic acid phosphohydrolase, or cyclooxygenase. Results. a… CONTINUE READING

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