Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expression.

@article{Shan2007MessengerRO,
  title={Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expression.},
  author={Xiu Shan and Yueming Chang and Chien-liang Glenn Lin},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 11},
  pages={2753-64}
}
We previously reported that up to 50% of messenger RNAs (mRNA) are oxidatively damaged in the affected area of Alzheimer's disease (AD) brains. The role of RNA oxidation in the cell death process is unknown. In the present study, we used cortical primary dissociated cultures to investigate the relationship between RNA oxidation and neuron degeneration induced by various insults, including hydrogen peroxide, glutamate, and amyloid beta peptide. These insults mediate the production of reactive… CONTINUE READING
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