Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells

@article{Cervera1981MessengerRI,
  title={Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells},
  author={Margarita Cervera and Gideon Dreyfuss and Sheldon Penman},
  journal={Cell},
  year={1981},
  volume={23},
  pages={113-120}
}
When the cytoskeletal framework is prepared from suspension-grown HeLa by extraction with nonionic detergent, all the polyribosomes are associated with the framework while 80% of tRNA and the major portion of monoribosomes as well as 75% of the cell proteins are found in the soluble fraction. The mRNA of polyribosomes is bound to the cytoskeleton and these molecules remain attached even after polyribosomes are disassembled in vivo prior to extraction. Although all actively translating message… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 84 CITATIONS, ESTIMATED 68% COVERAGE

FILTER CITATIONS BY YEAR

1981
2019

CITATION STATISTICS

  • 5 Highly Influenced Citations