Messenger RNA for the coat protein of tobacco mosaic virus
@article{Hunter1976MessengerRF, title={Messenger RNA for the coat protein of tobacco mosaic virus}, author={Tony Hunter and Tim Hunt and John Knowland and David Zimmern}, journal={Nature}, year={1976}, volume={260}, pages={759-764} }
TMV RNA is not an efficient template for translation of the viral coat protein, in spite of containing nucleo-tide sequences coding for the protein. Efficient translation requires the prior synthesis within infected cells of a smaller RNA carrying only a portion of the information encoded in the whole genome.
234 Citations
Regulation of Translation of Viral mRNAs
- Biology
- 1987
Viral genomes, and in particular viral RNA genomes, have served as model systems to investigate the steps involved in protein synthesis and have successfully helped to unravel the various strategies of translation known to occur on mRNA templates.
The Translation of Large Plant Viral RNAs
- Biology
- 1977
The following overview of plant viral translation will center on the viruses with large, presumably multigenic RNAs (molecular weight over 106) and the large components of the multicomponent viruses like the bromoviridae.
The initiation site for transcription of the TMV 30‐kDa protein messenger RNA
- BiologyFEBS letters
- 1984
Effects of the 5′-Leader Sequence of Tobacco Mosaic Virus RNA, or Derivatives Thereof, on Foreign mRNA and Native Viral Gene Expression
- Biology
- 1990
One such pleiotropic sequence, the 5′-untranslated leader of tobacco mosaic virus (TMV) RNA, is the main subject of this article.
Virus reconstitution and the proof of the existence of genomic RNA.
- BiologyPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
- 1999
This paper is a historical overview of the work done on the tobacco mosaic virus. The primary finding was that a virus is capable of reassembling itself from its component protein and RNA, and that…
Virus reconstitution and the proof of the existence of genomic RNA.
- BiologyBioEssays : news and reviews in molecular, cellular and developmental biology
- 1990
This paper is a historical overview of the work done on the tobacco mosaic virus. The primary finding was that a virus is capable of reassembling itself from its component protein and RNA, and that…
In vitro viral RNA synthesis by a subcellular fraction of TMV-inoculated tobacco protoplasts.
- Biology, ChemistryVirology
- 1986
Efficient translation of the coat protein cistron of tobacco mosaic virus in a cell-free system from Escherichia coli.
- BiologyEuropean journal of biochemistry
- 1982
Translation of tobacco mosaic virus RNA in a cell-free system derived from Escherichia coli reveals several discrete polypeptides in the Mr range of 10,000-50,000 which comigrates with authentic TMV coat protein on sodium dodecyl sulphate/polyacrylamide gel electrophoresis.
Synthesis of TMV-specific RNAs and proteins at the early stage of infection in tobacco protoplasts: transient expression of the 30K protein and its mRNA.
- Biology, ChemistryVirology
- 1984
Leaky UAG termination codon in tobacco mosaic virus RNA
- BiologyNature
- 1978
It is shown here that synthesis of these two proteins is initiated at the same site; the larger product is generated by partial readthrough of an amber (UAG) termination codon, and in the presence of yeast amber suppressor tRNA, the in vitro synthesis of the 160Kprotein is increased whereas the yield of the 110K protein is diminished.
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