Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients.

@article{Pachot2005MessengerRE,
  title={Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients.},
  author={Alexandre Pachot and Guillaume Monneret and Aur{\'e}lie Brion and Fabienne Venet and Julien Boh{\'e} and Jacques Bienvenu and Bruno Mougin and Alain Lepape},
  journal={Critical care medicine},
  year={2005},
  volume={33 1},
  pages={31-8; discussion 236-7}
}
OBJECTIVE The decreased expression of human leukocyte antigen (HLA)-DR on monocytes is proposed as a major feature of sepsis-induced immunodepression. The objective of the present study was to investigate, in whole blood from septic shock patients, the messenger RNA (mRNA) expression of a gene panel, which is essential to ensure major histocompatibility complex class II protein structure, transport, and peptide loading. DESIGN The authors conducted a cohort study. SETTING This study was… CONTINUE READING