Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.

@article{Saga1997Mesp2AN,
  title={Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.},
  author={Yumiko Saga and Nobuhiko Hata and Haruhiko Koseki and Makoto Mark Taketo},
  journal={Genes & development},
  year={1997},
  volume={11 14},
  pages={1827-39}
}
We isolated a novel bHLH protein gene Mesp2 (for mesoderm posterior 2) that cross-hybridizes with Mesp1 expressed in the early mouse mesoderm. Mesp2 is expressed in the rostral presomitic mesoderm, but down-regulated immediately after the formation of the segmented somites. To determine the function of MesP2 protein (MesP2) in somitogenesis, we generated Mesp2-deficient mice by gene targeting. The homozygous Mesp2 (-/-) mice died shortly after birth and had fused vertebral columns and dorsal… CONTINUE READING
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Mentioned Connections BETA
MesodermNo subtypeSomites
Mesp2 is expressed in the rostral presomitic mesoderm , but down - regulated immediately after the formation of the segmented somites .
SomitesNo subtypeMesoderm
Mesp2 is expressed in the rostral presomitic mesoderm , but down - regulated immediately after the formation of the segmented somites .
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