Mesotherapy for Facial Skin Rejuvenation: A Clinical, Histologic, and Electron Microscopic Evaluation

@article{Amin2006MesotherapyFF,
  title={Mesotherapy for Facial Skin Rejuvenation: A Clinical, Histologic, and Electron Microscopic Evaluation},
  author={Snehal P. Amin and Robert G. Phelps and David J. Goldberg},
  journal={Dermatologic Surgery},
  year={2006},
  volume={32},
  pages={1467–1472}
}
BACKGROUND AND OBJECTIVE Mesotherapy, as broadly defined, represents a variety of minimally invasive techniques in which medications are directly injected into the skin and underlying tissue in order to improve musculoskeletal, neurologic, and cosmetic conditions. There are few clinical studies evaluating the efficacy and safety of mesotherapy in any form. This study evaluates the histologic and clinical changes associated with one of the simplest formulations of mesotheraphy commonly used for… 

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References

SHOWING 1-7 OF 7 REFERENCES
Nonablative facial remodeling: erythema reduction and histologic evidence of new collagen formation using a 300-microsecond 1064-nm Nd:YAG laser.
TLDR
Microsecond Nd:YAG lasers appear to be safe for nonablative laser remodeling and can produce new collagen formation in the papillary dermis, indicating that the condition of patients with erythema may be improved.
Histological changes associated with mesotherapy for fat dissolution
  • P. Rose, M. Morgan
  • Medicine
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
  • 2005
TLDR
It is demonstrated that mesotherapy with PC and DC affects the subcutaneous fat, and it is theorize that the reduction of sub cutaneous fat likely follows inflammatory‐mediated necrosis and resorption.
Localized urticaria pigmentosa Triggered by Mesotherapy
TLDR
A new side effect consisting of an urticaria-pigmentosa-like eruption located at the sites of the injections is reported, commonly reported in patients with asymptomatic red brownish macules with moderate pruritus.
Cutaneous infection with Mycobacterium fortuitum after localized microinjections (mesotherapy) treated successfully with a triple drug regimen.
TLDR
Three women, aged 24, 27 and 44 years, presented with similar clinical features, consisting of painful nodules located at the points where mesotherapy had been applied, and a multidrug long-term regimen was needed to achieve resolution of the lesions.
Subcutaneous nodules showing fat necrosis owing to mesotherapy.
  • Deuk-Pyo Lee, S. Chang
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2005
TLDR
A 27-year-old woman who had been treated with seven sessions of mesotherapy once or twice a week to reduce localized abdominal subcutaneous fat (cellulite) noticed several erythematous tender nodules at the injection sites of the abdomen, but after 4 weeks, however, the nodules showed liquefaction, fat necrosis with ulceration, and yellowish serous discharge.
Detergent Effects of Sodium Deoxycholate Are a Major Feature of an Injectable Phosphatidylcholine Formulation Used for Localized Fat Dissolution
TLDR
The phosphatidylcholine formula popularly used in subcutaneous injections for fat dissolution works primarily as a detergent causing nonspecific lysis of cell membranes, suggesting a role in eliminating unwanted adipose tissue.
[What is mesotherapy?].
  • M. Pistor
  • Medicine
    Le Chirurgien-dentiste de France
  • 1976